Nonsense Mutation Correction in Human Diseases
An Approach for Targeted Medicine
(Sprache: Englisch)
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene,...
Leider schon ausverkauft
versandkostenfrei
Buch (Kartoniert)
66.99 €
Produktdetails
Produktinformationen zu „Nonsense Mutation Correction in Human Diseases “
Klappentext zu „Nonsense Mutation Correction in Human Diseases “
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
Features basic biological and clinical constructs that inform the application of genomic data to clinical decision-making Includes theories and methods that can be used to link bio-molecular and clinical phenotypes so as to enable integrative hypothesis discovery, testing, and downstream evidence-based practice Provides design patterns and use cases that contextualize the clinical decision-making and evidence-based practice relative to real world requirements and stakeholders
Inhaltsverzeichnis zu „Nonsense Mutation Correction in Human Diseases “
1. General aspects related to nonsense mutations 2. Pathologies susceptible to be targeted for nonsense mutation therapies 3. Strategies to correct nonsense mutations 4. Conclusions
Autoren-Porträt von Fabrice Lejeune, Hana Benhabiles, Jieshuang Jia
Dr. Fabrice Lejenue studies the mechanisms that regulate or deregulate the quality control of protein synthesis with the aim to one day utilize these mechanisms to chemically treat diseases such as cystic fibrosis, muscular dystrophy and cancer. He studied under Dr. Lynne Maquat, Director, Center for RNA Biology, and the scientist responsible for discovering the control mechanism messenger RNA carrying nonsense mutations in mammals. Dr. Lejeune continues this work at his lab at the Pasteur Institute.
Bibliographische Angaben
- Autoren: Fabrice Lejeune , Hana Benhabiles , Jieshuang Jia
- 2016, 190 Seiten, Maße: 23 cm, Kartoniert (TB), Englisch
- Verlag: Academic Press
- ISBN-10: 0128044683
- ISBN-13: 9780128044681
Sprache:
Englisch
Kommentar zu "Nonsense Mutation Correction in Human Diseases"
0 Gebrauchte Artikel zu „Nonsense Mutation Correction in Human Diseases“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Nonsense Mutation Correction in Human Diseases".
Kommentar verfassen