Occupational Cancers

Foreword [Harri Vainio]Chapter 1
Environmental and occupational factors of cancer [PB, SA]This chapter contains general information that assists understanding of the rest of the book, such as
- interpretation of epidemiological evidence and terminology
- classification of carcinogenic agents and factors
- introduction to molecular mechanisms of carcinogenesis
- host susceptibility factors, genetic and acquired (life-style and environment)
- biomarkers of exposure and disease; applications in research and practice
- means of prevention of occupational cancer
Chapter 2
Historical overview of occupational cancer research and control [Jack Siemiatycki]Chapter 3
Occupational cancer burden [PB]Contains epidemiological data from Western as well as low- and medium-resource countries
Chapter 4
Genetics and gene-environment interactions [Karl T. Kelsey]Chapter 5
Mechanisms of carcinogenesis [SA, Karl T. Kelsey]Chapters 6-23
6-23 Organ-specific chapters contain organized data (see example of lung cancer below) about occupational factors of specific cancers. Often the same chemical or physical agents may be occupational or related to life-style or environmental factors. Exposures other than occupational may have synergistic effect on the cancer risk and are important to discuss. Cancer sites and examples of occupational risk factors are listed below. Main chapters would include:
Cancer of the oral cavity, pharynx and nasopharynx [Daniele Luce]- risk factors : formaldehyde, wood dust, chlorophenols, pesticides, chromates, nickel, arsenic, welding fumes, textile dust, HPV, tobacco etc.
Cancers of the gastrointestinal tract [Farhad Islami, Farin Kamangar]- Oesophagus (adenocarcinoma): asbestos, cement dust, pesticides, acetaldehyde
- Cardia (adenocarcinoma): asphalt fumes, wood dust, pesticides
- Gastric cancer: cement dust, quartz, diesel exhaust, coal and tin mining, metal processing, rubber manufacturing, N-nitroso compounds etc.
Malignant tumours of the

Paolo Boffetta, MD, MPHBluhdorn Professor of International Community MedicineDirector, Institute for Translational EpidemiologyAssociate Director for Population Sciences, Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiOne Gustave L. Levy PlaceNew York, NY, USASisko Anttila MD, PhDHelsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Laboratory Services, HUSLAB, andFinnish Institute of Occupational Health, Helsinki, Finland.