Pathophysiology of Heart Failure

I. Cardiomyopathy and Contractile Dysfunction.- 1. Experimental models of heart failure and cardiomyopathy.- 2. Role of tissue and circulating substance P in cardiovascular injury associated with Mg-deficiency.- 3. Functional and metabolic effects of norepinephrine on the rat heart.- 4. Interventions in experimentally induced diabetic cardiomyopathy.- 5. Diabetes as a risk factor for cardiovascular disease: Experimental models.- 6. Ethanol-induced hypertension: the role of Acetaldehyde.- 7. Abnormalities in cardiac contractile proteins and cardiac dysfunction.- 8. Role of the slow sodium channel in hereditary cardiomyopathy.- 9. Cardiac contractile failure caused by disturbances in myofibrillar energy supply and pathogenesis of cardiomyopathies.- 10. Changes in contractile proteins under oxidative stress.- 11. Antioxidants and the heart.- 12. Gene expression of cardiac myocytes: a pharmacologic target for the failing heart?.- II. Calcium-Related Events and Heart Dysfunction.- 13. Regulation of slow Ca2+ channels of myocardial cells by cyclic nucleotides and phosphorylation.- 14. Multiple roles for the membrane-associated Ca2+/calmodulin-dependent protein kinase in the regulation of sarcoplasmic reticulum function in heart muscle.- 15. Calreticulin, a multifunctional Ca2+ binding protein of smooth muscle sarcoplasmic reticulum membranes.- 16. Intracellular Ca2+ transients in response to step length changes in aequorin-injected ferret papillary muscles.- 17. Initial changes in ?-adrenergic receptor function during development of rapid ventricular pacing-induced heart failure.- 18. Impaired cellular signaling of the adenylyl cyclase and the phosphoinositide pathway in septic cardiomyopathy.- 19. Defective G-protein expression and adenylyl cyclase in genetic andexperimental hypertension.- 20. Electrophysiological studies of wild-type and mutant Na+-Ca2+ exchange proteins.- 21. Cardiac sarcolemmal Na+/H+ exchange after a myocardial infarction in the rat.- 22. Myocardial