PDZ Mediated Interactions

Identification of PDZ Interactions by Yeast Two-Hybrid.- Identification of PDZ Interactions by Affinity Purification and Mass Spectrometry Analysis.- Identification of PDZ Interactions by Proteomic Peptide Phage Display.- A Computational Protocol to Analyze PDZ/PBM Affinity Data Obtained by High-Throughput Holdup Assay.- Study of PDZ-Peptide and PDZ-Lipid Interactions by Surface Plasmon Resonance/BIAcore.- PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations.- Crystallographic Studies of PDZ Domain-Peptide Interactions of the Scribble Polarity Module.- A Fluorescence-Based Assay to Determine PDZ-Ligand Binding Thermodynamics.- Unveiling the Folding Mechanism of PDZ Domains.- Development of Peptide-Based PDZ Domain Inhibitors.- Dynamic Control of Signaling by Phosphorylation of PDZ Binding Motifs.- Chemical Synthesis of PDZ Domains.- Viral PDZ Binding Motifs Influence Cell Behavior through the Interaction with Cellular Proteins Containing PDZ Domains.- Computational Design of PDZ:peptide Binding.- Mechanoregulation of PDZ Proteins, An Emerging Function.- Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains.