Peptaibiotics
Fungal Peptides Containing Alpha-Dialkyl Alpha-Amino Acids
(Sprache: Englisch)
Originally a special issue of Chemistry & Biodiversity, this is an excellent overview of the status of contemporary studies in peptaibiotics, covering aspects ranging from the search for novel bioactive compounds to considerations of their membrane-modifying properties.
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Originally a special issue of Chemistry & Biodiversity, this is an excellent overview of the status of contemporary studies in peptaibiotics, covering aspects ranging from the search for novel bioactive compounds to considerations of their membrane-modifying properties.
Klappentext zu „Peptaibiotics “
A few years ago, the non-coded amino acids Aib (alpha-aminoisobutyric acid) and Iva (isovaline) were considered to be exceedingly rare in the biosphere. Nowadays, the exploitation of Aib as highly specific marker amino acid for the detection of an abundance of fungal peptides that have been named comprehensively peptaibiotics is well established and coincidentally proves the abundance and ubiquity of the fungal producers in the biosphere. Peptaibiotics attract much attention owing to their broad range of bioactivities that comprise antimicrobial and insecticidal features, uncoupling of oxidative phosphorylation in mitochondria, induction of hypothermia, and neuroleptic effects in rodents, and include also the unique transmembrane-channel forming properties in lipid bilayer membranes.
This book, in reviews as well as original contributions, will boost the interest in peptaibiotics, and the methods of synthesis outlined are expected to pave the way for the target-oriented search and characterization of a myriad of new structures and bioactivities waiting to be explored by the scientific community.
Originally published as a special issue of Chemistry & Biodiversity, this volume provides an excellent overview of the status of contemporary studies in peptaibiotics. It covers aspects ranging from the search for novel bioactive compounds and their biosynthetic aspects to the total chemical synthesis and exploitation of X-ray diffraction and various spectroscopic techniques, to considerations of their membrane-modifying properties, including mechanisms of transmembrane channel formation through peptide self-association.
Inhaltsverzeichnis zu „Peptaibiotics “
1. Peptaibiotics and Peptaibols: An Alternative to Classical Antibiotics? (H. Duclohier)2. The History of Alamethicin: A Review of the Most Extensively Studied Peptaibol (B. Leitgeb, A. Szekeres, L. Manczinger, C. Vagvoelgyi, L. Kredics)
3. New Sequences, Constituents, and Producers of Peptaibiotics: An Updated Review (T. Degenkolb, J. Kirschbaum, H. Brueckner)
4. Facts and Challenges in the Understanding of the Biosynthesis of Peptaibols by Trichoderma (C. P. Kubicek, M. Komon-Zelazowska, E. Sandor, I. S. Druzhinina)
5. Peptaibiomics: Microheterogeneity, Dynamics, and Sequences of Trichobrachins, Peptaibiotics from Trichoderma parceramosum BISSETT (T. longibrachiatum RIFAI) (C. Krause, J. Kirschbaum, H. Brueckner)
6. Peptaibol Production by Sepedonium Strains Parasitizing Boletales (T. Neuhof, A. Berg, H. Besl, T. Schwecke, R. Dieckmann, H. von Doehren)
7. Peptaibols: Stable Markers of Fungal Development in the Marine Environment (L. Poirier, M. Montagu, A. Landreau, M. Mohamed-Benkada, O. Grovel, C. Sallenave-Namont, J.-F. Biard, C. Amiard-Triquet, J.-C. Amiard, Y. Francois Pouchus)
8. Total Synthesis in Solution and Conformational Analysis of the Peptaibol Cervinin and Selected Analogues (C. Baldini, M. Bellanda, C. Peggion, A. Legrand Djontu, C. Atagua, S. Mammi, C. Toniolo)
9. The "Azirine/Oxazolone Method" in Peptaibol Synthesis: Preparation of a Derivative of Trichotoxin A-50 (G) (W. Altherr, A. Linden, H. Heimgartner)
10. Synthesis, and Structural and Biological Studies of Efrapeptin C Analogues (M. Jost, S. Weigelt, T. Huber, Z. Majer, J.-C. Greie, K. Altendorf, N. Sewald)
11. Total Syntheses in Solution of TOAC-Labelled Alamethicin F50/5 Analogues (C. Peggion, M. Jost, C. Baldini, F. Formaggio, C. Toniolo)
12. Multinuclear Solid-State-NMR and FT-IR-Absorption Investigations on Lipid/Trichogin Bilayers (C. Heuber, F. Formaggio, C. Baldini, C. Toniolo, K. Mueller)
13. Antiamoebin I in Methanol Solution: Rapid Exchange
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between Right-Handed and Left-Handed 310-Helical Conformations (Z. O. Shenkarev, A. S. Paramonov, K. D. Nadezhdin, E. V. Bocharov, I. A. Kudelina, D. A. Skladnev, A. A. Tagaev, Z. A. Yakimenko, T. V. Ovchinnikova, A. S. Arseniev)
14. Solvent Effects on the Secondary Structure of the Membrane-Active Zervamicin Determined by PELDOR Spectroscopy (A. D. Milov, Y. D. Tsvetkov, E. Y. Gorbunova, L. G. Mustaeva, T. V. Ovchinnikova, J.-W. Handgraaf, J. Raap)
15. Conformational Analysis of TOAC-Labelled Alamethicin F50/5 Analogues (C. Peggion, M. Jost, W. M. De Borggraeve, M. Crisma, F. Formaggio, C. Toniolo)
16. Solvent Dependence of the Rotational Diffusion of TOAC-Spin-Labeled Alamethicin (D. Marsh, M. Jost, C. Peggion, C. Toniolo)
17. Supramolecular Structure of Self-Assembling Alamethicin Analog Studied by ESR and PELDOR (A. D. Milov, M. I. Samoilova, Y. D. Tsvetkov, M. Jost, C. Peggion, F. Formaggio, M. Crisma, C. Toniolo, J.-W. Handgraaf, J. Raap)
18. Alamethicin Interaction with Lipid Membranes: A Spectroscopic Study on Synthetic Analogues (L. Stella, M. Burattini, C. Mazzuca, A. Palleschi, M. Venanzi, I. Coin, C. Peggion, C. Toniolo, B. Pispisa)
19. Ligand-Induced Extramembrane Conformation Switch Controlling Alamethicin Assembly and the Channel Current (S. Futaki, K. Asami)
20. Channel-Forming Activity of Alamethicin: Effects of Covalent Tethering (G. Andrew Woolley)
21. Pore-Forming Properties of Alamethicin F50/5 Inserted in a Biological Membrane (N. Vedovato, C. Baldini, C. Toniolo, G. Rispoli)
22. Membrane Permeabilization of a Mammalian Neuroendocrine Cell Type (PC12) by the Channel-Forming Peptides Zervamicin, Alamethicin, and Gramicidin (A. F. Weidema, T. N. Kropacheva, J. Raap, D. L. Ypey)
23. The Peptaibol Alamethicin Induces an rRNA-Cleavage-Associated Death in Arabidopsis thaliana (S. Rippa, H. Adenier, M. Derbaly, L. Beven)
24. Neuroleptic Properties of the Ion-Channel-Forming Peptaibol Zervamicin: Locomotor Activity and Behavioral Effects (T. V. Ovchinnikova, N. G. Levitskaya, O. G. Voskresenskaya, Z. A. Yakimenko, A. A. Tagaev, A. Y. Ovchinnikova, A. N. Murashev, A. A. Kamenskii)
25. Enzymatic Reaction in a Vesicular Microreactor: Peptaibol-Facilitated Substrate Transport (T. N. Kropacheva, J. Raap)
26. Synthetic, Biologically Active Amphiphilic Peptides (C. R. Yamnitz, G. W. Gokel)
27. Index
14. Solvent Effects on the Secondary Structure of the Membrane-Active Zervamicin Determined by PELDOR Spectroscopy (A. D. Milov, Y. D. Tsvetkov, E. Y. Gorbunova, L. G. Mustaeva, T. V. Ovchinnikova, J.-W. Handgraaf, J. Raap)
15. Conformational Analysis of TOAC-Labelled Alamethicin F50/5 Analogues (C. Peggion, M. Jost, W. M. De Borggraeve, M. Crisma, F. Formaggio, C. Toniolo)
16. Solvent Dependence of the Rotational Diffusion of TOAC-Spin-Labeled Alamethicin (D. Marsh, M. Jost, C. Peggion, C. Toniolo)
17. Supramolecular Structure of Self-Assembling Alamethicin Analog Studied by ESR and PELDOR (A. D. Milov, M. I. Samoilova, Y. D. Tsvetkov, M. Jost, C. Peggion, F. Formaggio, M. Crisma, C. Toniolo, J.-W. Handgraaf, J. Raap)
18. Alamethicin Interaction with Lipid Membranes: A Spectroscopic Study on Synthetic Analogues (L. Stella, M. Burattini, C. Mazzuca, A. Palleschi, M. Venanzi, I. Coin, C. Peggion, C. Toniolo, B. Pispisa)
19. Ligand-Induced Extramembrane Conformation Switch Controlling Alamethicin Assembly and the Channel Current (S. Futaki, K. Asami)
20. Channel-Forming Activity of Alamethicin: Effects of Covalent Tethering (G. Andrew Woolley)
21. Pore-Forming Properties of Alamethicin F50/5 Inserted in a Biological Membrane (N. Vedovato, C. Baldini, C. Toniolo, G. Rispoli)
22. Membrane Permeabilization of a Mammalian Neuroendocrine Cell Type (PC12) by the Channel-Forming Peptides Zervamicin, Alamethicin, and Gramicidin (A. F. Weidema, T. N. Kropacheva, J. Raap, D. L. Ypey)
23. The Peptaibol Alamethicin Induces an rRNA-Cleavage-Associated Death in Arabidopsis thaliana (S. Rippa, H. Adenier, M. Derbaly, L. Beven)
24. Neuroleptic Properties of the Ion-Channel-Forming Peptaibol Zervamicin: Locomotor Activity and Behavioral Effects (T. V. Ovchinnikova, N. G. Levitskaya, O. G. Voskresenskaya, Z. A. Yakimenko, A. A. Tagaev, A. Y. Ovchinnikova, A. N. Murashev, A. A. Kamenskii)
25. Enzymatic Reaction in a Vesicular Microreactor: Peptaibol-Facilitated Substrate Transport (T. N. Kropacheva, J. Raap)
26. Synthetic, Biologically Active Amphiphilic Peptides (C. R. Yamnitz, G. W. Gokel)
27. Index
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Bibliographische Angaben
- 2009, XX, 480 Seiten, 220 farbige Abbildungen, Maße: 18,2 x 24,6 cm, Gebunden, Englisch
- Herausgegeben: Claudio Toniolo, Hans Brückner
- Verlag: Wiley-VCH
- ISBN-10: 3906390527
- ISBN-13: 9783906390529
Sprache:
Englisch
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