Peptides, Chemistry and Biology

INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and Main Conformational Features of the Peptide Bond
Building Blocks, Classification, and Nomenclature
Analysis of the Covalent Structure of Peptides and Proteins
Three-Dimensional Structure
Methods of Structural Analysis
BIOLOGY OF PEPTIDES
Historical Aspects and Biological Functions
Biosynthesis
Selected Biologically Active Peptides
PEPTIDE SYNTHESIS
Principles and Objectives
Protection of Functional Groups
Peptide Bond Formation
Racemization During Synthesis
Solid-Phase Peptide Synthesis (SPPS)
Biochemical Synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and Tactics
Solution Phase Synthesis (SPS)
NEW: Solution Phase/Solid Phase-Hybrid Approaches
Optimized Strategies on Polymeric Support
Chemical Ligation Strategies
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine Peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated Peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS
Peptide Design
Modified Peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and De-Novo Design of Peptides and Proteins
COMBINATORIAL PEPTIDE SYNTHESIS
Parallel Synthesis
Synthesis of Mixtures
APPLICATION OF PEPTIDES AND PROTEINS
NEW: General Manufacturing Strategies
NEW: Improvement of the Therapeutic Potential
Protein Pharmaceuticals
Peptide Pharmaceuticals
PEPTIDES IN PROTEOMICS
NEW: Genome and Proteome
NEW: Separation Methods
NEW: Peptide and Protein Analysis in Proteomics
NEW: Activity-Based Proteomics

Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry and bioactive peptides.

Hans-Dieter Jakubke is a now retired Professor of Chemistry at the University of Leipzig, Germany, where he worked in and taught peptide chemistry for several decades. He is also an experienced writer, having authored several popular German language textbooks and encyclopedias on various aspects of chemistry and biochemistry.