Perinatal Stem Cells
(Sprache: Englisch)
Thorough update of the field-defining text
Now includes contributions from international authors
Written by a diverse group of researchers representing OB/GYNs, hematologists, blood bank scientists and tissue engineers
Includes new chapters on the...
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Produktinformationen zu „Perinatal Stem Cells “
Thorough update of the field-defining text
Now includes contributions from international authors
Written by a diverse group of researchers representing OB/GYNs, hematologists, blood bank scientists and tissue engineers
Includes new chapters on the growing perinatal stem cell industry .
Klappentext zu „Perinatal Stem Cells “
Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers.Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.
With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.
Inhaltsverzeichnis zu „Perinatal Stem Cells “
Contributors xiIntroduction xv
1 AMNIOTIC FLUID STEM CELLS 1
Sean Vincent Murphy and Anthony Atala
Introduction 1
Development of Gestational Stem Cells 2
Isolation and Characterization of Amniotic Fluid Stem Cells 2
Multipotency of Amniotic Fluid Stem Cells 3
Clinical Application of Amniotic Fluid Stem Cells 8
Conclusion 13
References 13
2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17
Richard L. Haspel and Karen K. Ballen
Introduction 17
Hematopoietic Stem Cell Transplants: Adult Donor Collection 17
Hematopoietic Stem Cell Transplants: HLA Matching 18
Collection and Processing of Cord Blood Units 19
Hematopoietic Stem Cell Transplants: Recipient Issues 20
Bone Marrow versus Single Cord Blood: Pediatric 21
Bone Marrow versus Cord Blood: Adults 23
Cord Blood Transplant: Advantages and Disadvantages 23
Double Cord Blood Transplants: Ablative Regimens 24
Double Cord Blood Transplant: Non-Myeloablative Regimens 26
Are Two Cords Better Than One? 27
Chimerism 28
Predicting the Winner 28
Other Experimental Strategies 30
Summary 31
References 31
3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37
Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola
Introduction 37
The Hematopoietic System 37
Historical Perspective on Placental Hematopoiesis 38
The Development and Structure of the Mouse Placenta 39
Hematopoietic Activity in the Mouse Placenta 40
Identification of Placental HSCs 42
The Origin and Localization of Placental HSCs 43
Hematopoietic Activity in the Human Placenta 45
Hematopoietic Microenvironment in the Placenta 46
Conclusions and Perspectives 47
References 49
4 PERINATAL
... mehr
MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE 53
Rouzbeh R. Taghizadeh
Introduction 53
Hematopoiesis 54
Hematopoietic Transplantations 54
Umbilical Cord: Source of Perinatal HSCs and MSCs 56
Hematopoietic Transplantations of Umbilical Cord Blood 57
Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58
Umbilical Cord Tissue MSC Banking 61
References 63
5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71
Hans Klingemann
Introduction 71
MSC to Prevent Rejection After Solid Organ Transplantation 72
MSC in the Treatment of Graft-versus-Host Disease 73
MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74
References 75
6 WHARTON'S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77
Rita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La Rocca
Introduction 77
Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79
Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79
Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80
WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82
Conclusions and Future Perspectives 83
References 84
7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89
Bram Lutton and Raimon Duran-Struuck
Introduction 89
Rouzbeh R. Taghizadeh
Introduction 53
Hematopoiesis 54
Hematopoietic Transplantations 54
Umbilical Cord: Source of Perinatal HSCs and MSCs 56
Hematopoietic Transplantations of Umbilical Cord Blood 57
Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58
Umbilical Cord Tissue MSC Banking 61
References 63
5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71
Hans Klingemann
Introduction 71
MSC to Prevent Rejection After Solid Organ Transplantation 72
MSC in the Treatment of Graft-versus-Host Disease 73
MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74
References 75
6 WHARTON'S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77
Rita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La Rocca
Introduction 77
Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79
Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79
Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80
WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82
Conclusions and Future Perspectives 83
References 84
7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89
Bram Lutton and Raimon Duran-Struuck
Introduction 89
... weniger
Bibliographische Angaben
- 2013, 2. Aufl., 320 Seiten, Maße: 15 x 25 cm, Gebunden, Englisch
- Herausgegeben: Kyle Cetrulo, Curtis L. Cetrulo, Rouzbeh R. Taghizadeh
- Verlag: Wiley & Sons
- ISBN-10: 1118209443
- ISBN-13: 9781118209448
Sprache:
Englisch
Pressezitat
"A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources." ( Pediatric Endocrinology Reviews , 1 June 2014)Kommentar zu "Perinatal Stem Cells"
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