Pharmaceutical Process Chemistry

PART 1: INTRODUCTORY REMARKS From Milligrams to Tons: The Importance of Synthesis & Process Research in the Development of New DrugsPART 2: FUTURE APPLICATIONSDesign of Dynamic Salt Catalysts Based on Acid-Base Combination ChemistryAsymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile OxidantNew Methods for the Functionalization of Aromatic CompoundsStreamlining Synthesis via C-H OxidationByproduct-Free C-C Bond Formation via Catalytic Hydrogenation and Transfer HydrogenationEnzymo-Metallic Dynamic Kinetic Resolution as a New Tool for Chiral SynthesisSome Progress of Organic Synthesis of Pharmaceuticals in ChinaPART 3: USEFUL SYNTHTIC TECHNOLOGIES Boron Reagents in Process Chemistry: Excellent Tools for Selective ReductionsCommercialization of a Sodium Hydride Mediated Arylation ProcessAn Entirely New Methodology for Synthesizing Perfluorinated CompoundsApplication of Whole-Cell Biocatalysts in the Manufacture of Fine ChemicalsPART 4: CONSTRUCTION OF EFFICIENT PRACTICAL PROCESSES Synthetic Studies on the Halichondrin B Analog, Eribulin MesylateProcess Development of An Anthracycline Anticancer DrugProcess Development of HIV Integrase Inhibitor S-1360An Efficient Synthesis of the PKC Inhibitor JTT-010Practical Process Development of KRP-103 for Treatment of Urinary IncontinenceDevelopment of a Novel Synthetic Method for RNA OligomersPART 5: USEFUL ENGINEERING TECHNOLOGIESProcess Research with Explosive ReactionsNovel Resolution Technologies Controlled by Effectively Designed Molecular Recognition MechanismDevelopment on New Drug and Crystal PolymorphMeasurements and Mechanism of Drying of Active Pharmaceutical IngredientsMatching Chemistry with Chemical Engineering for Optimum Design and Performance of Pharmaceutical ProcessingDesign Space for Drug Substance - the Approach used for Vandetanib

Takayuki Shioiri is President of the Japanese Society for Process Chemistry since 2001. He received his B. A. in 1959 and M. A. in 1961 from University of Tokyo. During his Ph. D. course, he was appointed a research associate at University of Tokyo in 1962. After obtaining his Ph. D. degree in 1967, he worked for Prof. D. H. R. Barton as a postdoctoral fellow at the Imperial College from 1968 to 1970. He returned to his alma mater and promoted to Associate Professor in 1977. In the same year, he was appointed Professor of Nagoya City University. He retired from Nagoya City University and became Emeritus Professor in 2001. Since 2002, he was Professor of Graduate School of Environmental and Human Sciences, Meijo University. He retired from Meijo University in 2007 and is now an adjunct Professor of Graduate School of Environmental and Human Sciences, Meijo University. He was a recipient of 1993 Pharmaceutical Society of Japan Award and 1999 Japanese Peptide Society Award. From 1990 to 2007, he was a Japan Regional Executive Editor of the international journal Tetrahedron and he is experienced book author. He was President of the Japanese Peptide Society from 2000 to 2002.