Pharmacogenetics and Individualized Therapy
(Sprache: Englisch)
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves...
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Produktinformationen zu „Pharmacogenetics and Individualized Therapy “
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Klappentext zu „Pharmacogenetics and Individualized Therapy “
The one-stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practicesPharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level-and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics.
The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.
Including chapters on specific therapeutic areas and clinical aspects, Pharmacogenetics and Individualized Therapy helps readers, whether they're students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics.
Inhaltsverzeichnis zu „Pharmacogenetics and Individualized Therapy “
- Preface (Dr A. H. Maitland-van der Zee and Dr A. K. Daly)1.Pharmacogenetics: a historical perspective (Dr A. K. Daly)
- Pharmacogenetics: relationship to pharmacokinetics and pharmacodynamics
2. Pharmacogenetics in drug metabolism: Role of Phase I enzymes (Dr V. Dolzan)
3. Pharmacogenetics of phase II drug metabolizing enzymes (Prof I. Cascorbi)
4. Pharmacogenetics of drug transporters (Henriette E. Meyer zu Schwabedissne, Markus Grube, Prof. Heyo K. Kroemer)
5. Pharmacogenetics of drug targets (Dr M. Arranz and Prof A. Daly)
- Pharmacogenetics in different therapeutic areas
6. Cardiovascular Pharmacogenetics (Bas J. M. Peters, Prof. Anthonius de Boer, Prof. Tom Schalekamp, Prof. H. Klungel, Anke-Hilse Maitland-van der Zee, PharmaD PhD)
7. Pharmacogenetics in psychiatry (Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Ann K. Daly, Katherine J. Aitchison)
8. Pharmacogenetics in cancer (Dr S. Marsh)
9. Pharmacogenetics of Asthma and COPD (E. Koster, Dr G. H. Koppelman, Dr J.A. M. Raaijmakers, Dr A. H. Maitland-van der Zee)
10. Pharmacogenetics of adverse drug reactions (Prof. Ann K. Daly, Dr. Martin Armstrong and Prof. Munir Pirmohamed)
11. Pharmacogenomics of inflammatory bowel diseases (Dr. Alexander Teml, Dr. Susanne Karner, Dr. Elke Schaeffeler, Prof. Matthias Schwab)
12. Pharmacogenetics of pain medication (Dr. J. Loetsch)
- Pharmacogenetics: implementation in clinical practice
13. Ethical and social issues in pharmacogenetics testing (S. Vijverberg, Dt T. Pieters and Dr M. Cornel)
- Developments in Pharmacogenetic Research
14. High-throughput genotyping technologies for pharmacogenetics (Beatriz Sobrino and Dr. Angel Carracedo)
15. Developments in analyses in pharmacogenetic datasets (Dr A. Motsinger)
- Pharmacogenetics in industry and in regulatory affairs
16. Applications of Pharmacogenetics in Pharmaceutical Research and Development (Dr. Daniel K. Burns and Dr. Scott S.
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Sundseth)
17. Role of Pharmacogenetics in Registration Process (Dr. Myong-Jin Kim, Dr. Issam Zineh, Dr. Shiew-Mei Huang, and Dr. Lawrence J. Lesko)
- Conclusions
18. Pharmacogenetics: possibilities and pitfalls (Dr A. H. Maitland-van der Zee and Dr A. K. Daly)ain medication (Dr. J. Loetsch)
- Pharmacogenetics: implementation in clinical practice
13. Ethical and social issues in pharmacogenetics testing (S. Vijverberg, Dt T. Pieters and Dr M. Cornel)
- Developments in Pharmacogenetic Research
14. High-throughput genotyping technologies for pharmacogenetics (Beatriz Sobrino and Dr. Angel Carracedo)
15. Developments in analyses in pharmacogen
17. Role of Pharmacogenetics in Registration Process (Dr. Myong-Jin Kim, Dr. Issam Zineh, Dr. Shiew-Mei Huang, and Dr. Lawrence J. Lesko)
- Conclusions
18. Pharmacogenetics: possibilities and pitfalls (Dr A. H. Maitland-van der Zee and Dr A. K. Daly)ain medication (Dr. J. Loetsch)
- Pharmacogenetics: implementation in clinical practice
13. Ethical and social issues in pharmacogenetics testing (S. Vijverberg, Dt T. Pieters and Dr M. Cornel)
- Developments in Pharmacogenetic Research
14. High-throughput genotyping technologies for pharmacogenetics (Beatriz Sobrino and Dr. Angel Carracedo)
15. Developments in analyses in pharmacogen
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Autoren-Porträt von Maitland-van de, Daly
ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands.ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.
Bibliographische Angaben
- Autoren: Maitland-van de , Daly
- 2012, 1. Auflage, 512 Seiten, Maße: 16,1 x 24 cm, Gebunden, Englisch
- Herausgegeben: Anke-Hilse Maitland-van der Zee, Ann K. Daly
- Verlag: Wiley & Sons
- ISBN-10: 047043354X
- ISBN-13: 9780470433546
- Erscheinungsdatum: 04.06.2012
Sprache:
Englisch
Rezension zu „Pharmacogenetics and Individualized Therapy “
"This is a well-written book that I highly recommend to anyone interested in any aspect of personalized medicine." (Doody's, 24 August 2012 )
Pressezitat
"This is a well-written book that I highly recommend to anyone interested in any aspect of personalized medicine." (Doody's, 24 August 2012 )Kommentar zu "Pharmacogenetics and Individualized Therapy"
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