Pharmacogenomics
Methods and Protocols
(Sprache: Englisch)
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain...
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Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
Klappentext zu „Pharmacogenomics “
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions. Pharmacogenomics holds the promise of drugs tailor-made to an individual's geneticmakeup for greater efficacy and safety. In Pharmacogenomics: Methods and Protocols, expert researchers and physician/clinicians describe in detail the newest and most common technologies now used in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromatography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions. The protocols
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follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and highly practical, Pharmacogenomics: Methods and Protocols offers pharmacologists, geneticists, molecular biologists, and clinical chemists working in academia, biotechnology, and the pharmaceutical industry a cutting-edge collection of the key techniques used for today's preclinical and clinical studies.
Comprehensive and highly practical, Pharmacogenomics: Methods and Protocols offers pharmacologists, geneticists, molecular biologists, and clinical chemists working in academia, biotechnology, and the pharmaceutical industry a cutting-edge collection of the key techniques used for today's preclinical and clinical studies.
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Inhaltsverzeichnis zu „Pharmacogenomics “
Part I. History and OverviewPharmacogenomics: Historical Perspective and Current StatusWerner KalowPart II. Functional Analysis of Gene VariationTransfection Assays With Allele-Specific Constructs: Functional Analysis of UDP-Glucuronosyltransferase VariantsHideto Jinno, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Yoshiro Saito, Shogo Ozawa, and Jun-ichi SawadaSnapshot of the Allele-Specific Variation in Human Gene ExpressionHai YanGenome-Wide Analysis of Allele-Specific Gene Expression Using Oligo MicroarraysMaxwell P. LeeHaploChIP: An In Vivo AssayJulian Charles KnightPart III. Genotyping TechniquesAspects Influencing Genotyping Method SelectionPeter ImleDenaturing High-Performance Liquid Chromatography for Mutation Detection and GenotypingDonna Lee Fackenthal, Pei Xian Chen, and Soma DasPyrosequencing of Clinically Relevant PolymorphismsSharon Marsh, Cristi R. King, Adam A. Garsa, and Howard L. McLeodKinetic Fluorescence-Quenching Detection Assay for Allele Frequency EstimationMing Xiao and Pui-Yan KwokMatrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass SpectrometryMatthias Wjst and Dirk van den BoomFluorescence-Based Fragment Size AnalysisPeter ImleSingle-Nucleotide Polymorphism Genotyping in DNA PoolsIan Craig, Emma Meaburn, Lee Butcher, Linzy Hill, and Robert PlominTaqMan Genotyping of Insertion/Deletion PolymorphismsRenato Robledo, William R. Beggs, and Patrick K. BenderPart IV. Management of Pharmacogenomic InformationPharmGKB: The Pharmacogenetics and Pharmacogenomics Knowledge BaseCaroline F. Thorn, Teri E. Klein, and Russ B. AltmanSystems for the Management of Pharmacogenomic InformationAlexander Sturn, Michael Maurer, Robert Molidor, and ZlatkoTrajanoskiIndex
Bibliographische Angaben
- 2005, 214 Seiten, Maße: 23,5 cm, Gebunden, Englisch
- Herausgegeben von Innocenti, Federico
- Verlag: Humana Press
- ISBN-10: 1588294404
- ISBN-13: 9781588294401
Sprache:
Englisch
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