Principles of Bone Biology

Physiological Actions of Parathyroid Hormone and PTH-Related Protein Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Chapter 36: Vitamin D Gene Regulation Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Chapter 39: Amylin and Calcitonin Gene-Related Peptide E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens & Progestins Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Chapter 42: Mechanisms of Estrogen Action in Bone Chapter 43: Thyroid Hormone & Bone Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Chapter 47: Kinins & Neuro-Osteogenic Factors Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Chapter 50: Platelet-Derived Growth Factor & the Skeleton Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Chapter 53: Transforming Growth Factor-â Chapter 54: Bone Morphogenetic Proteins and the Skeleton Chapter 55: Bone Morphogenetic Protein Receptors & Actions Chapter 56: Colony-Stimulating Factor-1 Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Chapter 58: Prostaglandins & Bone Metabolism Carol Pilbeam Part II Molecular Mechanisms of Metabolic Bone Disease Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Chapter 60: Molecular Basis of PTH Overexpression Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Chapter 62: Multiple Endocrine Neoplasia Type I Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy Chapter 64: Local Factors in Skeletal Malignancy Chapter 65: Genetic Regulation of the Parathyroid Gland Development Chapter 66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Chapter 67: Diseases Resulting from Defects in the G Protein Gs Chapter 68: Renal Osteodystrophy - Pathogenic Mechanisms and Therapeutic Options Chapter 69: Osteogenesis Imperfecta Chapter 70: Hereditary Deficiencies in Vitamin D Action Chapter 71: Oncogenic Osteomalacia Chapter 72: Osteopetrosis Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Chapter 74: Paget's Disease of Bone Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Chapter 76: Pathophysiology of Osteoporosis Chapter 77: Evaluation of Risk for Osteoporosis Fracture Part III Pharmacological Mechanisms of Therapeutics Chapter 78: Parathyroid Hormone Chapter 79: Calcium Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Chapter 81: Bisphosphonates: Mechanisms of Action Chapter 82: The Pharmacology of Estrogens in Osteoporosis Chapter 83: Vitamin D & Analogs Chapter 84: Estrogen Effects on Bone in the Male Skeleton Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality

Part IV Methods in Bone Research Chapter 86: Application of Transgenic Mice to Problems of Skeletal Bone Chapter 87: Biochemical Markers of Bone Metabolism Chapter 88: Methods and Clinical Issues in Bone Densitometry Chapter 89: Controversial Issues in Bone Densitometry Chapter 90: Macro and Micro Imaging of Bone Architecture

Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry. Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.