Protein Synthesis and Targeting in Yeast
(Sprache: Englisch)
Due to fundamental similarities between the yeastSaccharomyces cerevisiae and multicellular organisms at themolecular level, and the powerful range of experimentaltools available for this yeast, S. cerevisiae is proving anideal model system for studies on...
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Klappentext zu „Protein Synthesis and Targeting in Yeast “
Due to fundamental similarities between the yeastSaccharomyces cerevisiae and multicellular organisms at themolecular level, and the powerful range of experimentaltools available for this yeast, S. cerevisiae is proving anideal model system for studies on protein synthesis andtargeting.The topics covered are: - Messenger RNA stability andtranslation.- The translation apparatus. - Translationalcontrol andfidelity. - Protein targeting to themitochondrion. - Nuclear transport. - The secretory pathway.- Protein folding and degradation. - Protein splicing.Modern and often novel molecular, genetic and biochemicalapproaches as well as most recent data are provided. Thereader will gain a comprehensive view of the current statusof the field.
Inhaltsverzeichnis zu „Protein Synthesis and Targeting in Yeast “
- Mrna Stability and Translation1. Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay
2. RNA14 and RNA15, two proteins regulating mRNA stability in Saccharomyces cerevisiae
3. Translational control in Saccharomyces cerevisiae studies in vivo and in vitro
- The Ribosome
4. Thoughts on the regulation of ribosome synthesis in Saccharomyces cerevisiae
5. Regulation of ribosomal protein synthesis in yeasts (Saccharomyces and Kluyveromyces)
6. The evolution of ribosomal proteins and yeast
7. The acidic ribosomal proteins and the control of protein synthesis in yeast
- Translational Fidelity
8. SUP35 and SUP45 genes code for ribosome-bound proteins involved in the control of translational fidelity in yeast
9. Mutations affecting translational accuracy in yeast
10. Dosage-dependent modifiers of psi'-dependent omnipotent suppression in yeast
11. Aberrant mRNA decoding by the dimorphic yeast Candida albicans
- Translation Factors
12. Effect of initiation factor eIF-5A depletion on cell proliferation and protein synthesis
13. Analysis of the genes encoding eIF-4A from yeast
14. Uncharged tRNA and derepression of the general amino acid control: autoregulation of yeast lysyl-tRNA synthetase
- Translation in the Mitochondrion
15. Positive control of translation in organellar genetic systems
16. Translation in yeast mitochondria
17. Yeast mitochondrial translation: nuclear genes involved in the expression of the mitochondrial genome
- Mitochondrial Import and Sorting
18. Early events in protein import into mitochondria
19. Targeting pathways to the mitochondrial inner membrane
20. Intra-mitochondrial sorting of precursor proteins
21. Genetic characterization of the intermembrane space sorting domains of yeast cytochrome b2
22. Mitochondrial import of cytochrome C
- Nuclear Transport
23. Using yeast to study exchange of macromolecules between the cytoplasm and the nucleus
24. Nucleocytoplasmic
... mehr
transport in ribosome biogenesis
25. Approaches towards a genetic analysis of the nuclear pore complex in yeast
- Targeting to the Endoplasmic Reticulum and Beyond
26. The SRP-dependent protein targeting pathway in Saccharomyces cerevisiae
27. Similarities between Scerevisiae Sec 61p and E. coli SecY suggest a common origin for protein translocases of the eukaryotic ER and the bactenal plasma membrane
28. ATP transport into yeast ER is a prerequisite for preprotein transfer across the ER membrane
29. Cross-linking signal sequences to components of yeast microsomes
30. The nucleotide cycle of SEC4 is important for its function in vesicular transport
31. Vacuolar protein sorting in yeast
32. Eukaryotic MDR1/P-glycoprotein homologues: unconventional secretion processes mediated by a growing family of ATP-dependent membrane translocators
- Intracellular Protein Folding
33. The role of protein disulfide isomerase in yeast
34. Novel chaperone-like pro-sequences allow secretion of recombinant human insulin-like growth factor-1 from yeast
35. mRNA translation and protein folding in vivo
- Protein Splicing and Degradation
36. Protein splicing of yeast TFP1: evidence for a new class of mobile genetic elements
37. Ubiquitin-dependent protein degradation
38. The TIF463A and TIF463B genes encode the large subunits of the yeast cap binding protein complex
25. Approaches towards a genetic analysis of the nuclear pore complex in yeast
- Targeting to the Endoplasmic Reticulum and Beyond
26. The SRP-dependent protein targeting pathway in Saccharomyces cerevisiae
27. Similarities between Scerevisiae Sec 61p and E. coli SecY suggest a common origin for protein translocases of the eukaryotic ER and the bactenal plasma membrane
28. ATP transport into yeast ER is a prerequisite for preprotein transfer across the ER membrane
29. Cross-linking signal sequences to components of yeast microsomes
30. The nucleotide cycle of SEC4 is important for its function in vesicular transport
31. Vacuolar protein sorting in yeast
32. Eukaryotic MDR1/P-glycoprotein homologues: unconventional secretion processes mediated by a growing family of ATP-dependent membrane translocators
- Intracellular Protein Folding
33. The role of protein disulfide isomerase in yeast
34. Novel chaperone-like pro-sequences allow secretion of recombinant human insulin-like growth factor-1 from yeast
35. mRNA translation and protein folding in vivo
- Protein Splicing and Degradation
36. Protein splicing of yeast TFP1: evidence for a new class of mobile genetic elements
37. Ubiquitin-dependent protein degradation
38. The TIF463A and TIF463B genes encode the large subunits of the yeast cap binding protein complex
... weniger
Bibliographische Angaben
- 2014, Softcover reprint of the original 1st ed. 1993, XV, 414 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Alistair J. P. Brown, Mick Tuite, John E.G. McCarthy
- Verlag: Springer, Berlin
- ISBN-10: 3642849237
- ISBN-13: 9783642849237
- Erscheinungsdatum: 14.04.2014
Sprache:
Englisch
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