Replicating Vaccines

SECTION 1: Today¿s Live Attenuated Vaccines.- Live Vaccines and their Role in Modern Vaccinology.- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster.- Classical Live Viral Vaccines.- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines.- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus.- Live Attenuated Shigella Vaccines. Is encouraging good enough?.- New generation BCG vaccines.- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines.- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines.- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches.- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread.- RSV Deletion Mutant ¿ Innate Immunity.- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity.- SECTION 4: New Types of Replicating Vaccines.- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors.- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines.- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines.- Alphavirus Particle-based Vaccine Vectors.- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.

From the reviews:"This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. ... Given the renaissance in vaccinology this is a timely volume which ... makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field." (Paul Duprex, Microbiology Today, November, 2011)