RP-HPLC Method for the Determination of Sertraline
(Sprache: Englisch)
A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4.6mm, 5µm) using a mobile phase...
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A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4.6mm, 5µm) using a mobile phase consisting of ammonium acetate buffer and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.8ml/min at ambient temperature. The quantification was achieved with UV detection at 273nm. The linearity was observed over the concentration range of 50-250µg/ml with a correlation coefficient of 0.999. The accuracy of the proposed method was determined by recovery studies and found to be 98-100.3% of Sertraline. The proposed method can be employed for routine quality control analysis of Sertraline in tablet dosage forms.
Bibliographische Angaben
- Autoren: L. Kalyani , A. Lakshmana Rao
- 2014, 92 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3659587206
- ISBN-13: 9783659587207
Sprache:
Englisch
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