Sherlock's Diseases of the Liver and Biliary System

List of Contributors.

Preface to the Twelfth Edition.

Preface to the First Edition.

1 Anatomy and Function (Jay H. Lefkowitch).

2 Assessment of Liver Function (Sandeep Mukherjee & John L. Gollan).

3 Biopsy of the Liver (David Patch & Amar Paul Dhillon).

4 Haematological Disorders of the Liver (Pramod K. Mistry & Dhanpat Jain).
5 Acute Liver Failure (Shannan R. Tujios & William M. Lee).

6 Hepatic Fibrogenesis (Meena B. Bansal & Scott L. Friedman).

7 Hepatic Cirrhosis (P. Aiden McCormick).

8 Hepatic Encephalopathy in Patients with Cirrhosis (Marsha Y. Morgan).

9 The Hepatic Artery, Portal Venous System and Portal Hypertension: the Hepatic Veins and Liver in Circulatory Failure (Andrew K. Burroughs).

10 Ascites (Guadalupe Garcia-Tsao).

11 Jaundice and Cholestasis (Elwyn Elias).

12 Gallstones and Benign Biliary Diseases (James S. Dooley).

13 Malignant Biliary Diseases (Rahul S. Koti & Brian R. Davidson).

14 Cysts and Congenital Biliary Abnormalities (Giorgina Mieli-Vergani & Nedim Had~ic).
ycystic dis
Fibropoleases.

15 Primary Biliary Cirrhosis (Margaret F. Bassendine).

16 Sclerosing Cholangitis (Simon Rushbrook & Roger W. Chapman).

17 Enterically Transmitted Viral Hepatitis: Hepatitis A and Hepatitis E (Peter Karayiannis & Howard C. Thomas).

18 Hepatitis B (Anna S. F. Lok).

19 Hepatitis D (Patrizia Farci).

20 Hepatitis C (Geoffrey Dusheiko).

21 Hepatitis due to Non-A-E Viruses (Antonio Craxì & Rosa Di Stefano).

22 HIV and the Liver (Marion G. Peters & Vincent Soriano).

23 Autoimmune Hepatitis and Overlap Syndromes (Gideon M. Hirschfi eld & E. Jenny Heathcote).

24 Drug-Induced Liver Injury (Leonard B. Seeff & Robert J. Fontana).

25 Alcohol and the Liver (Stephen Stewart & Chris Day).

26 Iron Overload States (Paul Adams).

27 Wilson's Disease (Eve A. Roberts).

28 Non-alcoholic Fatty Liver Disease and Nutrition (Stephen H.

About the Editors:

James Dooley, Editor-in-Chief, worked with Professor Dame Sheila Sherlock on this book for three editions before her death in December 2001. He is a Consultant Hepatologist at the Royal Free Hospital, London.

Andrew Burroughs is a Consultant Physician and Hepatologist at the Royal Free Hospital, Liver Transplantation and Hepato-biliary Medicine Unit. He qualified in Liverpool with a MB ChB Honours in 1976, gained his MRCP in 1978 and FRCP in 1991. He is a Fellow of the European Board of Gastroenterology. He has been Scientific Secretary of the European Association for the Study of the Liver 1997-1999. He continues his association with EASL as administrative secretary until 2001. He is a council member of the United European Gastroenterology Federation until 2002, and a council member of the International Association for the Study of the Liver. He is a member of the MRC advisory board in the UK, from 1997 onwards. He was a member of Council of the British Society of Gastroenterology from 1992 to 1995. Andrew Burroughs main research interests are portal hypertension, variceal bleeding and coagulopathy, primary biliary cirrhosis, prognosis in liver disease and liver transplantation. He has published over 200 peer-reviewed articles.

Anna Lok is a Professor of Internal Medicine and the Director of Clinical Hepatology at the University of Michigan Medical Center. Her research focuses on the epidemiology and treatment of hepatitis B and C viruses. Millions of people worldwide are infected and are at risk for hepatitis-associated cirrhosis and hepatocellular carcinoma. Dr. Lok has made seminal contributions to our understanding of the natural history of hepatitis B and the role of hepatitis B virus genotypes and variants in the outcome of chronic hepatitis B infection. She has also made contributions to the treatment of hepatitis-induced diseases. She is currently testing new antiviral therapies for hepatitis B, developing cost-effective methods

"This is a concise, updated, and well-written book that justifies replacing the previous edition. It is definitively useful and exhibits the same high quality of other currently available books in hepatology. I know I will consult my copy on a frequent basis -- an unusual event in this era of online material." (Doody's, 16 March 2012) "James Dooley is to be congratulated on his courage and dedication along with his clearly inspiring leadership to contributing authors has not allowed Sheila's volume to die with her passing. The Hepatology world, has been given a thoroughly up-to-date, exciting and cleverly produced volume which competitors will have greatest difficulty in matching." (Institute of Hepatology, 2011)

"This is a concise, updated, and well-written book that justifies replacing the previous edition. It is definitively useful and exhibits the same high quality of other currently available books in hepatology. I know I will consult my copy on a frequent basis -- an unusual event in this era of online material." (Doody s, 16 March 2012)

"James Dooley is to be congratulated on his courage and dedication along with his clearly inspiring leadership to contributing authors has not allowed Sheila s volume to die with her passing. The Hepatology world, has been given a thoroughly up-to-date, exciting and cleverly produced volume which competitors will have greatest difficulty in matching." (Institute of Hepatology, 2011)