Stroke Genomics

Part I. Introduction Introduction to Stroke Genomics Simon J. Read and Frank C. Barone Part II. Preclinical Models and Gene Manipulation Choice, Methodology, and Characterization of Focal Ischemic Stroke Models: The Search for Clinical Relevance David Virley Mutant Animal Models of Stroke and Gene Expression: The Stroke-Prone Spontaneously Hypertensive Rat Hilary V. O. Carswell, Martin W. McBride, Delyth Graham, Anna F. Dominiczak, and I. Mhairi Macrae Gene Therapy in Neurological Disease Midori A. Yenari and Robert M. Sapolsky Stem Cell Transplantation After Middle Cerebral Artery Occlusion Paul Stroemer and Helen Hodges Endogenous Brain Protection: Models, Gene Expression, and Mechanisms Frank C. Barone Production of Transgenic and Mutant Mouse Models Alex J. Harper 3-Nitropropionic Acid Model of Metabolic Stress: Assessment by Magnetic Resonance Imaging Toby John Roberts Part III. Clinical Paradigms Practicalities of Genetic Studies in Human Stroke Ahamad Hassan and Hugh S. Markus Evaluation of the Interactions of Common Genetic Mutations in Stroke Zoltán Szolnoki Part IV. Assessing Differential Expression Technologies of Disease-Related Gene Discovery Using Preclinical Models of Stroke Xinkang Wang Quantitative Analysis of Gene Transcription in Stroke Models Using Real-Time RT-PCR David C. Harrison and Brian C. Bond Effective Analysis of Genomic Data Paul R. Nelson, Andrew B. Goulter, and Richard J. Davis Bioinformatic Approaches to Assigning Protein Function From Novel Sequence Data David Michalovich and Richard Fagan Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target: The Interleukin-1 Story Stuart McRae Allan Indexf

From the reviews:"The protocols presented in Stroke Genomics: Methods and Reviews will greatly benefit scientists interested in the molecular biology as well as the genetic and genomic basis of strokes." - Journal of Chemical Neuroanatomy"...very interesting and informative...an attractive and interesting overview of the different aspects of the current stroke research...can be recommended as a source of useful and up-to-date practical and theoretical information on stroke genetics and on stroke associated gene expression." - European Neurology"This book gives the opportunity for experts in the field to explore the practical and experimental applications of genomic and molecular biology research to the treatment of stroke. ... The book also indicates detailed methods for studying the molecular biology of stroke. ... It can be recommended if one is interested in the basic scientific background that underlies central nervous system pathology ... ." (J. V. Byrne, Neuroradiology, Vol. 47, 2005)