Sustainable Flow Chemistry

Foreword
 
FLOW PHOTOCHEMISTRY - A GREEN TECHNOLOGY WITH A BRIGHT FUTURE
Introduction to Synthetic Organic Photochemistry
Conventional Batch Photochemistry
Continuous-Flow Chemistry
Selected Examples of Photochemical Reactions under Flow Conditions
Summary, Conclusion, and Outlook
 
CONTINUOUS FLOW SYNTHESIS USING RECYCLABLE REACTION MEDIA
Introduction
Continuous Flow Reactions Using an Ionic Liquid
Continuous Flow Reactions Using a Fluorous Solvent
Conclusions
 
SYNTHESIS AND APPLICATION OF H2O2 IN FLOW REACTORS
Introduction
The Synthesis of Hydrogen Peroxide from Hydrogen and Oxygen in Flow Process with Microtechnology
Application of Hydrogen Peroxide in Microreactors
Conclusions
 
SCALE-UP OF FLOW PROCESSES IN THE PHARMACEUTICAL INDUSTRY
Introduction
Stages of Pharmaceutical Development
Sustainability of Supply - The Role of Continuous Processing
Comparison of Batch to Continuous Large-Scale Processing
Scale-Up of a Flow Process
Flow Processes in the Manufacture of Pharmaceuticals: Examples of Scale-Up
Summary and Outlook on Future Scale-Up
 
ORGANIC SYNTHESIS IN FLOW: TOWARD HIGHER LEVELS OF SUSTAINABILITY
Introduction
Semi-Automated Optimization
Self-Optimizing Microreactor Systems
Sustainability in Microreactor Technology
Conclusion
 
SUSTAINABLE FLOW CHEMISTRY IN DRUG DISCOVERY
Introduction
Laboratory Equipment
Advantages of Improved Sustainability
Sustainable Drug Discovery
Conclusions and Outlook
 
FLOW TOOLS TO DEFINE WASTE/TIME/ENERGY-MINIMIZED PROTOCOLS
Introduction
Minimization of Solvents and Reuse of Catalytic Systems
Time/Cost/Energy Saving Examples Using Flow Approach
Conclusions
 
THE APPLICATION OF FLOW CHEMISTRY IN THE USE OF HIGHLY REACTIVE INTERMEDIATES AND REAGENTS
Introduction
Hydrogenation Reactions in Flow
Carbonylation in Flow
Organometallic Reagents in Flow
Synthesis of Azides and Diazoacetates in Flow
The Use of Flow Reactors to Prepare

Luigi Vaccaro is a Professor of Organic Chemistry (habilitated in 2013 as full Professor) at the Università degli Studi di Perugia-Italy and is a Guest Professor (Bijzonder Gastdocent) at the University of KU Leuven-Belgium. He is also an Associate Editor of the journals RSC Advances and Beilstein Journal of Organic
Chemistry, and a member of the FWO WT&4 Chemistry expert panel and of the OECD-EPA commission on substitution of toxic substances. Prof. Vaccaro is leading the Green S.O.C. group in Perugia and is dedicating his research and teaching activity to the development of sustainable tools for minimizing waste and accessing cleaner products. He is currently focusing on the identification and use of novel biomass-derived solvents and on the design and synthesis of novel polymeric matrices for the preparation of heterogeneous catalytic systems suitable for being used in flow and green reaction media. Recent applications are directed toward the definition of
sustainable protocols for cross-coupling and C-H activation processes aimed at the clean synthesis of organic semiconductors and target materials. Luigi
Vaccaro is author of ca. 130 scientific publications and received the Europa Medal from Society of Chemical Industry - London (2001), the ADP Award
from Merck's Chemistry Council for "Creative work in organic chemistry" (2006 and 2007), the G. Ciamician Medal of the Società Chimica Italiana (2007) and the Vigevani Visiting Professorship (2014).