Synthesis of Some Dihydropyrimidinones and Pharmacological Activity
Synthesis of Dihydropyrimidinone Derivatives and Study of their Anti-Inflammatory Activity
(Sprache: Englisch)
This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen-containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins, and pyrimidines, etc. A mixture of substituted aldehydes...
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This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen-containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins, and pyrimidines, etc. A mixture of substituted aldehydes (0.01 mol) like acetylacetone (method 1) or ethyl acetoacetate (method 2), urea or thiourea (0.01 mol) and lemon juice (0.5 ml) were taken into a round bottom flask and reflux for 1 hour under continuous stirring. After completion of the reaction, the final product was recrystallized for purification. Simultaneously toxicity and anti-inflammatory activity were performed. But in case of using ethyl acetoacetate in method 2, the percentage yield was more as compared to using acetylacetone in method 1. So the derivatives obtained from method 2 were selected for further toxicity and anti-inflammatory activities.
Autoren-Porträt von Tirthankar Choudhury
Choudhury, TirthankarThe author completed his B.Pharm (2005), M.Pharm in Pharmaceutical Chemistry (2008), and Ph.D. (2012). Presently author is pursuing F.I.C. Total Teaching/ Research Experience is more than 12 years. The author is a Member of P.C.I. The author published different Research/Review articles in different National and International journals.
Bibliographische Angaben
- Autor: Tirthankar Choudhury
- 2020, 52 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6202673168
- ISBN-13: 9786202673167
Sprache:
Englisch
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