Systems Biology
(Sprache: Englisch)
Reflecting the latest developments, this textbook explains how quantitative and computable genotype-phenotype relationships can be built using a genome-wide basis of information about the gene portfolio of an organism. It has been developed through...
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Reflecting the latest developments, this textbook explains how quantitative and computable genotype-phenotype relationships can be built using a genome-wide basis of information about the gene portfolio of an organism. It has been developed through extensive classroom use, providing a conceptual framework in addition to invaluable modelling tools and computational approaches.Inhaltsverzeichnis zu „Systems Biology “
Preface; 1. Introduction; Part I. Network Reconstruction: 2. Network reconstruction: the concept; 3. Network reconstruction: the process; 4. Metabolism in Escherichia coli; 5. Prokaryotes; 6. Eukaryotes; 7. Biochemical reaction networks; 8. Metastructures of genomes; Part II. Mathematical Properties of Reconstructed Networks: 9. The stoichiometric matrix; 10. Simple topological network properties; 11. Fundamental network properties; 12. Pathways; 13. Use of pathway vectors; 14. Randomized sampling; Part III. Determining the Phenotypic Potential of Reconstructed Networks: 15. Dual causality; 16. Functional states; 17. Constraints; 18. Optimization; 19. Determining capabilities; 20. Equivalent states; 21. Distal causation; Part IV. Basic and Applied Uses: 22. Environmental parameters; 23. Genetic parameters; 24. Analysis of omic data; 25. Model driven discovery; 26. Adaptive laboratory evolution; 27. Model driven design; Part V. Conceptual Foundations: 28. Teaching systems biology; 29. Epilogue; References; Index.Bibliographische Angaben
- Autor: Bernhard Ø. Palsson
- 550 Seiten, Maße: 17,5 x 25 cm, Gebunden, Englisch
- Verlag: Cambridge University Press
- ISBN-10: 1107038855
- ISBN-13: 9781107038851
- Erscheinungsdatum: 09.04.2015
Sprache:
Englisch
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