The Design and Analyis of Sequential Clinical Trials
(Sprache: Englisch)
In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients...
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In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results.
Klappentext zu „The Design and Analyis of Sequential Clinical Trials “
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
Inhaltsverzeichnis zu „The Design and Analyis of Sequential Clinical Trials “
Clinical Trials.Allocating Patients to Treatments.
Measurement of Treatment Difference.
The Design of a Sequential Trial Using the Boundaries Approach.
The Analysis of a Sequential Trial.
Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.
Prognostic Factors.
The Comparison of More than Two Treatments.
Implementation of Sequential Methods: Some Examples.
References.
Appendix.
Index.
Bibliographische Angaben
- Autor: John Whitehead
- 1997, 2. Aufl., XIV, 314 Seiten, Maße: 15,7 x 23,5 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0471975508
- ISBN-13: 9780471975502
- Erscheinungsdatum: 23.07.1997
Sprache:
Englisch
Rezension zu „The Design and Analyis of Sequential Clinical Trials “
"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)
Pressezitat
"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)
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