The Involvement of Lipoxygenases in Inflammatory Signalling Pathways of Human Sebocytes in Vitro
(Sprache: Englisch)
Acne is a common disease affecting the majority of young people. The inflammation in the sebaceous gland plays a major role in the pathogenesis of acne. Lipoxygenases form a family of lipid peroxidising enzymes. Among lipoxygenases, the functions of...
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Acne is a common disease affecting the majority of young people. The inflammation in the sebaceous gland plays a major role in the pathogenesis of acne. Lipoxygenases form a family of lipid peroxidising enzymes. Among lipoxygenases, the functions of 5-lipoxygenase are well understood thanks to the implication of leukotrienes. Leukotriene B4 is the most potent pro-inflammatory mediator. We demonstrate that sebocytes, cells full of lipids, express both 5- and 15-lipoxygenase. Moreover leukotriene B4 as well pro-inflammatory cytokines are released by sebocytes after lipoxygenase activation. Human sebocytes possess the enzyme machinery to produce leukotriene B4. A reduction of leukotriene B4 seems to be effective in acne skin lesions and thereafter able to anameliorate acne.
Autoren-Porträt von Theodosios Alestas
Alestas, TheodosiosTheodosios Alestas graduated from medical school at the University of Athens, Greece, and trained in cell and molecular biology at the Department of Dermatology, Charité Universitaetsmedizin Berlin, Germany, and the Istituto Dermatologico San Gallicano, Rome, Italy. He is specialized in Dermatology and Venereology at the Andreas Syggros Hospital, University of Athens, Greece. His main research interest is the pro-inflammatory mechanisms in acne.
Bibliographische Angaben
- Autor: Theodosios Alestas
- 2008, 120 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639047125
- ISBN-13: 9783639047127
Sprache:
Englisch
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