The Molecular Basis of Human Cancer

Part I. IntroductionCancer Epidemiology: Incidence and Etiology of Human NeoplasmsWilliam B. Coleman and Gregory J. TsongalisPart II. Essential Concepts in Molecular BiologyEssential Concepts and Techniques in Molecular BiologySharon Collins PresnellPart III. Molecular Themes in OncogenesisCancer GenesJohn J. ReinartzPositive Mediators of Cell Proliferation in Neoplastic TransformationJames N. Welch and Susan A. ChrysogelosInactivation of Negative Growth Regulators During Neoplastic TransformationKara N. Smolinski and Stephen J. MeltzerPart IV. Mechanisms of MutationThe Role of Genomic Instability in the Development of Human CancerWilliam B. Coleman and Gregory J. TsongalisChromosomes and Chromosomal Instability in Human CancerTakashi Shimamoto and Kazuma OhyashikiHereditary CancerBruce M. Boman, Lael Melchert, and Jeremy Z. FieldsPart V. Etiology of Human CancersEvolution of Research in Cancer EtiologyLorenzo Tomatis and James HuffCellular Responses to Chemical CarcinogensEdward L. Loechler, Bryan Henry, and Kwang-Young SeoPhysical Agents in Human CarcinogenesisCynthia R. Timblin, Yvonne Janssen-Heininger, and Brooke T. MossmanViral Mechanisms of Human CarcinogenesisFelix Hoppe-Seyler and Karin ButzPart VI. Human Tumor SystemsThe Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction PathwayJ. Milburn Jessup, Gary Gallick, and Bo LiuMolecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and HepatoblastomaJoe W. GrishamThe Molecular Basis of Breast CarcinogenesisApril Charpentier and C. Marcelo AldazThe Molecular Basis of Prostate CarcinogenesisAllen C. Gao and John T. IsaacsThe Molecular Basis of Lung CarcinogenesisKwun M. Fong, Yoshitaka Sekido, and John D. MinnaThe Molecular Basis of Skin CarcinogenesisCaterina Missero, Mariarosaria D'Errico, Gian Paolo Dotto, and Eugenia DogliottiThe Molecular Biology of LeukemiasArnold B. Gelb and L. Jeffrey MedeirosMolecular Genetic

"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." -- Annals of Oncology

"This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." --Quarterly Review of Biology