The Unfolded Protein Response and Cellular Stress, Part A
(Sprache: Englisch)
The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both...
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The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and promotes the production of chaperone proteins that act to relieve this problem. If this problem cannot be corrected, the mechanism can initiate programmed cell death. Aspects of this unfolded protein response (UPR) are conserved from yeast to man, an observation that suggests a key role in the process of maintaining a living cell. The UPR presents a way of understanding cellular regulation, a mechanism for disease and a therapeutic opportunity. This first of three parts provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. Authors were selected based on research contributions in the area about which they have written and based on their ability to describe their methodological contribution in a clear and reproducible way. They have been encouraged to make use of graphics, comparisons to other methods, and to provide tricks and approaches not revealed in prior publications that make it possible to adapt methods to other systems.
Klappentext zu „The Unfolded Protein Response and Cellular Stress, Part A “
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.
Inhaltsverzeichnis zu „The Unfolded Protein Response and Cellular Stress, Part A “
Section I: UPR and Cell Stress in Normal and Diseased Cells
The Unfolded Protein Response in Mouse Cerebral Cortex Nirinjini Naidoo Immunohistochemical Detection of the Unfolded Protein Response in Atherosclerotic Plaques Sárka Lhoták and Richard C. Austin The role of PDI as a survival factor in cardiomyocyte ischemia Stefano Toldo; Anna Severino; Antonio Abbate; Alfonso Baldi Measurement of the Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals Guenther Boden and Salim Merali Measurement of the unfolded protein response (UPR) in monocytes Tomás P. Carroll, Catherine M. Greene, and Noel G. McElvaney Assessment of Endurance Exercise Training in Hepatic Endoplasmic Reticulum (ER) Stress Natalie Ann Chapados Discovery approaches to UPR in athero - susceptible endothelium in vivo Mete Civelek, Elisabetta Manduchi, Gregory Grant, Christian J. Stoeckert Jr, Peter F. Davies Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells Ines Witte & Sven Horke Measuring the impact of cigarette smoke on the UPR Hong Zhao, Jin Yang, Lin Shan and Ellen D. Jorgensen Induction and measurement of UPR and osmotic stress in the yeast Pichia pastoris Martin Dragosits, Diethard Mattanovich and Brigitte Gasser Induction of ER stress response leading to programmed cell death in Trypanosoma brucei Hanoch Goldshmidt and Shulamit Michaeli Measurement of Activation of the Endoplasmic Reticulum Stress Response in Autoimmune Myositis Heather M. Alger, Sree Rayavarapu and Kanneboyina Nagaraju Activation of the unfolded protein response in human acute myeloid leukemia Julian A. Schardt , Beatrice U. Mueller and Thomas Pabst Modulation of the Unfolded Protein Response by GRP78 in Prostate Cancer Gustaaf de Ridder, Rupa Ray, Uma K. Misra and Salvatore V. Pizzo Endoplasmic Reticulum Stress In Brain Damage Ram Raghubir, Venkata Prasuja Nakka, and Suresh L.Mehta Methods and Models for
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Monitoring UPR associated Macrophage Death during Advanced Atherosclerosis Edward B. Thorp Detecting Autophagy in Response to ER Stress Signals in Cancer Guillermo Velasco, María Salazar, Sonia Hernández-Tiedra, Sofía Torres, Mar Lorente, Manuel Guzmán The Unfolded Protein Response Induced By Salt Stress in Arabidopsis Miaoying Wang, Qiangyi Xu, and Ming Yuan Measurement of ER Stress Response and Inflammation in the Mouse Model of Non-alcoholic Fatty Liver Disease Ze Zheng , Chunbin Zhang, Kezhong Zhang
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Bibliographische Angaben
- 2011, 432 Seiten, Maße: 16,1 x 23,6 cm, Gebunden, Englisch
- Herausgegeben:Conn, P. Michael
- Herausgegeben: P. Michael Conn
- Verlag: Academic Press
- ISBN-10: 0123851165
- ISBN-13: 9780123851161
Sprache:
Englisch
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