The Unfolded Protein Response and Cellular Stress, Part C

Section I: New Approaches to Studying UPR and Cell Stress
CFTR Expression Regulation by the Unfolded Protein Response Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy Thomas C. Chen Targeting the Unfolded Protein Response in Cancer Therapy Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan Large-scale analysis of UPR-mediated apoptosis in human cells Andrew M. Fribley, Justin R. Miller, Tyler E. Reist1, Michael U. Callaghan and Randal J. Kaufman Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur Animal models in the study of the unfolded protein response Hemamalini Bommiasamy and Brian Popko Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett Analysis of nelfinavir-induced endoplasmic reticulum stress Ansgar Brüning Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo Alexander Gow Glycoprotein maturation and the UPR Andreas J. Hülsmeier, Michael Welti and Thierry Hennet Monitoring and Manipulating Mammalian Unfolded Protein Response Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin A screen for mutants requiring activation of the unfolded protein response for viability Guillaume Thibault and Davis T.W. Ng Signalling Pathways of Proteostasis Network Unrevealed By Proteomic Approaches on The Understanding of Misfolded Protein Rescue Patrícia Gomes-Alves, Sofia Neves and Deborah Penque Decreased Secretion and Unfolded Protein Response Up-Regulation Carissa L. Young, Theresa Yuraszeck, Anne S. Robinson Measuring signaling by the unfolded protein response David Cox, Natalie Strudwick, Ahmed A. Ali, Adrienne W. Paton, James C. Paton, and Martin Schröder Unfolded Protein

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on