The world of microRNA-377 and multiple sclerosis
Targeting miRNA in multiple sclerosis
(Sprache: Englisch)
One of the most recent studies in genetics has examined the role of microRNAs as biological markers for the diagnosis of multiple sclerosis. There are small and large plaques in the white matter of the brain and spinal cord. miR377-3p, formerly called...
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One of the most recent studies in genetics has examined the role of microRNAs as biological markers for the diagnosis of multiple sclerosis. There are small and large plaques in the white matter of the brain and spinal cord. miR377-3p, formerly called has-miR-377-3p, is located in the chromosomal region 32q14 and is in the SOD gene. SOD (dismutase superoxide dismutase) is a gene present in the chromosomal region 22q21 and the protein encoded by this gene is the enzyme superoxide dismutase. The aim of this study was to investigate the expression of miR-377 in patients with RRMS (recurrent multiple sclerosis) and healthy individuals who had no history of autoimmune or inflammatory disease. According to the results, miR-377-3p expression was higher in patients than healthy subjects (P = 0.036) and the sensitivity and diagnostic value of miRNA were equal to 0.80 AUC and the results were in accordance with previous studies and miR-377-3p May It can be used as a trademark to diagnose multiple sclerosis.
Autoren-Porträt von Majid Amini Khorasgani, Mohammad Hedayati, Parisa Eyvazi
Amini Khorasgani, MajidMajid Amini Khorasgangani. He has a bachelor's degree in microbiology and a master's degree in genetics and has been working in the laboratory and pharmaceutical industry since 2011. After working in this field for some time, he found interest in research in MS and psychiatric diseases and published several articles in these fields.
Bibliographische Angaben
- Autoren: Majid Amini Khorasgani , Mohammad Hedayati , Parisa Eyvazi
- 2020, 56 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6200563659
- ISBN-13: 9786200563651
Sprache:
Englisch
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