Trem-2 And Its Role In Alzheimer's
and Other Neurodegenerative Disorders
(Sprache: Englisch)
Alzheimer's disease (AD), is a chronic neurodegenerative disease that causes senile decay of neurons It is the cause of 60-70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. Genetic factors such as rare...
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Alzheimer's disease (AD), is a chronic neurodegenerative disease that causes senile decay of neurons It is the cause of 60-70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. Genetic factors such as rare variants of TREM2(triggering receptor expressed on myeloid cells-2) strongly increase the risk of developing AD, confirming the role of microglia in AD pathogenesis. In the last 5 years, several studies have dissected the mechanisms by which TREM2, as well as its rare variants affect amyloid and tau pathologies and their consequences in both animal models and in human studies. In this review, we summarize increases in our understanding of the involvement of TREM2 and microglia in AD development that may open new therapeutic strategies targeting the immune system to influence AD pathogenesis.
Autoren-Porträt von Dileep Kumar, Seshadri Kadambi
Kumar, DileepDr. Dileep Kumar is an Assistant Professor at Poona College of Pharmacy, Pune. He did his B.Pharm from Manipal University Manipal. Dr. D. Kumar completed his Ph.D. from IIT(BHU) Varanasi. He has published many international papers and book chapters.
Bibliographische Angaben
- Autoren: Dileep Kumar , Seshadri Kadambi
- 2021, 60 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6203926523
- ISBN-13: 9786203926521
Sprache:
Englisch
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