Tumor-Associated Fibroblasts and their Matrix

Preface. I. Overview. 1.Critical roles of stromal fibroblasts in the cancer microenvironments.II. Stromal Cell Diversity. 2. Functional diversity of fibroblasts. 3.The role of the myofibroblast in fibrosis and cancer progression. 4.The role of myofibroblasts in communicating tumor ecosystems. 5.Tumor vessel associated pericytes . 6.The role of Cancer-Associated Adipocytes (CAA) in the dynamic interaction between the tumor and the host.III.The Tumor ECM. 7. Hyaluronan: a key microenvironmental mediator of tumor-stroma cell interaction. 8.Function of Tenascins in the Tumor Stroma. 9. Fibulins and their role in the ECM. 10.Tumor fibroblast associated metalloportease. IV. Tumor modulating-fibroblast interactions. 11.Multiple fibroblast phenotypes in cancer patients: heterogeneity in expression of migration stimulating factor. 12.TGF-ß Signaling in fibroblasts regulated tumor initiation and progression in adjacent epithelia. 13. SDF-1 rich in tumour microenvironment provides aniche for carcinoma cells. 14.Role of PDGF in tumor stroma interactions. 15. Radiation-induced microenvironments and their role in carcinogenesis. V. Tumor-modulating ECM interactions. 16. The extracellular matrix as a multivalent signaling scaffold that orchestrates tissue organization and function. 17. SPARC and the tumor micoenvironment. 18.Integrin-extracellular matrix Interaction. 19.The multifaceted role of cancer associated fibroblasts in tumor progression. VI. Therapeutic application/targeting. 20.Cancer Associated fibroblasts as therapeutic target. 21. Targeting Tumor Associated Fibroblasts and Chemotherapy. 22. Antibody-based targeting of tumor vasculature and stroma.