Vistas in Quinolones Chemistry
(Sprache: Englisch)
Summary The aim of the present work is to design and synthesize binary, fused, spiro and polynuclear ring systems containing quinolone and evaluate its biological value such as antioxidant agents and antitumor agents. Thus, in the light of the...
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Summary The aim of the present work is to design and synthesize binary, fused, spiro and polynuclear ring systems containing quinolone and evaluate its biological value such as antioxidant agents and antitumor agents. Thus, in the light of the aforementioned importance of 7-methoxyquinolin-2,4(1H,3H)-dione and its derivatives, the present work is planned to investigate their behavior towards various reagents. Therefore, the sequences of these reactions followed for the preparation of the designed compounds in this thesis are summarized in Scheme 1-5. Synthesis of fused compounds containing quinolone 7-methoxyquinolin-2,4(1H,3H)-dione (1) was reacted with DMF/DMA in DMF to yield 2. While ,beta-unsaturated ketones 3-5 were afforded by conventional Claisen-Schmidt condensation by refluxing compound 1 with a variety of aldehydes namely; p-methoxylbenzaldehyde, 4-chlorobenzaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 2-hydroxybenzaldehyde, thiophene-2-carbaldehyde, and 1,3-diphenyl-1H-pyrazole-4-carbaldehyde, respectively. Also, refluxing compound 1 with cinnamaldehyde gave compound 6 and after dilution yielded compound 7 (Scheme 1).
Autoren-Porträt von Wafaa Hamama, Hanafi Zoorob, Alaa Hassanien
Hamama, WafaaWafaa Salama Hamama: graduated from Faculty of Science, Mansoura University where she was awarded the MSc and PhD in Chemistry from Faculty of Science, Mansoura University in 1978 and 1983, respectively. She was awarded Assistant Professor in 1988 then Professor in 2001 until now. She worked in Um-El Koura University in Saudi Arabia.
Bibliographische Angaben
- Autoren: Wafaa Hamama , Hanafi Zoorob , Alaa Hassanien
- 2018, 92 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3659885762
- ISBN-13: 9783659885761
Sprache:
Englisch
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