Mass Spectrometry Handbook
(Sprache: Englisch)
Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering...
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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields. Enables readers to select and implement the most effective mass spectrometry methodsFor decades, mass spectrometry has been the dominant force in analytical chemistry, offering unparalleled levels of sensitivity and selectivity for trace analysis and an impressive range of applications across numerous research disciplines. Now in one expertly written, edited, and organized reference, the Mass Spectrometry Handbook brings together the best tested and proven mass spectrometry methods available.
The Handbook provides a unique reference that allows for easy access to a variety of real-world applications that involve mass spectrometry. Each chapter in the Handbook provides essential background and history, detailed analytical methodology, and valuable references. Readers will obtain a step-by-step guide through the most popular and effective methods for each application. The exciting applications--starting with life sciences and culminating with specialized analytical techniques--are featured:
Biotechnology/Proteins
Environmental
Pharmaceutical
Geological
Clinical Analysis
Archaeology
Forensics
Surface Analysis
Space Exploration
Polymers
Homeland Security
Analytical Techniques
Food Analysis
Each chapter has
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been written by one or more leading international experts in the field of mass spectrometry. These authors have thoroughly examined the current literature in order to present the state of the technology. Moreover, based on their own firsthand laboratory experience, they explain why particular methods work or don't work for particular research objectives. References at the end of each chapter serve as a gateway to the most important studies in the field.
With its tremendous breadth and depth of coverage, the Mass Spectrometry Handbook is an excellent resource for practicing mass spectrometrists as well as for novices who want to quickly master the many applications and methods of mass spectrometry.
With its tremendous breadth and depth of coverage, the Mass Spectrometry Handbook is an excellent resource for practicing mass spectrometrists as well as for novices who want to quickly master the many applications and methods of mass spectrometry.
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Inhaltsverzeichnis zu „Mass Spectrometry Handbook “
FOREWORD xiPREFACE xiii
CONTRIBUTORS xvii
SECTION I BIOTECHNOLOGY/PROTEINS 1
1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3
Karen R. Jonscher, Lei Jin, John C. Cambier, Shaikh M. Rahman, and Jacob E. Friedman
2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23
Navin Rauniyar and Laszlo Prokai
3 Imaging Mass Spectrometry (IMS) for Biological Application 41
Yuki Sugiura, Ikuko Yao, and Mitsutoshi Setou
4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85
George W. Jackson, Rafal Drabek, Mithil Soni, Roger McNichols, Richard C. Willson, and George E. Fox
SECTION II PHARMACEUTICAL 107
5 Preclinical Pharmacokinetics: Industrial Perspective 109
Ayman El-Kattan and Manthena Varma
6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119
Wenying Jian, Wilson Shou, Richard W. Edom, Naidong Weng, and Mingshe Zhu
7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171
Xiaoying Xu, Wenkui Li, and Francis L.S. Tse
8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191
Margrét Thorsteinsdóttir, Baldur Bragi Sigur?sson, and Gísli Bragason
9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209
Kevin A. Schug
10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products 227
Igor A. Kaltashov, Cedric E. Bobst, and Rinat R. Abzalimov
11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243
Satoka Aoyagi
12 Accelerator Mass Spectrometry in Pharmaceutical Development 259
Benjamin J. Stewart, Graham Bench, Bruce A. Buchholz, Kurt W. Haack, Michael A. Malfatti, Ted J. Ognibene, and Kenneth W.
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Turteltaub
SECTION III CLINICAL ANALYSIS 271
13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273
Donald H. Chace
14 Mass Spectrometry for Steroid Analysis 297
William J. Griffi ths, Michael Ogundare, Anna Meljon, and Yuqin Wang
SECTION IV FORENSICS 339
15 Forensic Applications of Isotope Ratio Mass Spectrometry 341
Sarah J. Benson
16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373
Michael E. Sigman and C. Douglas Clark
SECTION V SPACE EXPLORATION 389
17 Mass Spectrometry in Solar System Exploration 391
Paul V. Johnson, Luther W. Beegle, and Isik Kanik
18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407
Jonathan S. Watson
SECTION VI HOMELAND SECURITY 417
19 Methods of Mass Spectrometry in Homeland Security Applications 419
Ünige A. Laskay, Erin J. Kaleta, and Vicki H. Wysocki
20 Homeland Security 441
Christina L. Crawford and Herbert H. Hill, Jr.
21 Mass Spectrometry in Homeland Security 477
Yasuaki Takada
22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491
Gary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham, and John E. Olson
23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509
R. Steven Pappas
SECTION VII FOOD ANALYSIS 529
24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications 531
Maciej Stobiecki, Piotr Kachlicki, and Henryk Jeleñ
25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559
Clifton K. Fagerquist and Omar
SECTION III CLINICAL ANALYSIS 271
13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273
Donald H. Chace
14 Mass Spectrometry for Steroid Analysis 297
William J. Griffi ths, Michael Ogundare, Anna Meljon, and Yuqin Wang
SECTION IV FORENSICS 339
15 Forensic Applications of Isotope Ratio Mass Spectrometry 341
Sarah J. Benson
16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373
Michael E. Sigman and C. Douglas Clark
SECTION V SPACE EXPLORATION 389
17 Mass Spectrometry in Solar System Exploration 391
Paul V. Johnson, Luther W. Beegle, and Isik Kanik
18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407
Jonathan S. Watson
SECTION VI HOMELAND SECURITY 417
19 Methods of Mass Spectrometry in Homeland Security Applications 419
Ünige A. Laskay, Erin J. Kaleta, and Vicki H. Wysocki
20 Homeland Security 441
Christina L. Crawford and Herbert H. Hill, Jr.
21 Mass Spectrometry in Homeland Security 477
Yasuaki Takada
22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491
Gary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham, and John E. Olson
23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509
R. Steven Pappas
SECTION VII FOOD ANALYSIS 529
24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications 531
Maciej Stobiecki, Piotr Kachlicki, and Henryk Jeleñ
25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559
Clifton K. Fagerquist and Omar
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Autoren-Porträt von Michael S. Lee
Mike S. Lee is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.
Bibliographische Angaben
- Autor: Michael S. Lee
- 2012, 1. Auflage, 1368 Seiten, Maße: 22,5 x 29,5 cm, Gebunden, Englisch
- Herausgegeben: Mike S. Lee
- Verlag: Wiley & Sons
- ISBN-10: 047053673X
- ISBN-13: 9780470536735
Sprache:
Englisch
Rezension zu „Mass Spectrometry Handbook “
"In summary, this handbook presents research from a variety of areas tied together by the common thread of mass spectrometry. The authors present their works in a manner that is accessible to beginning researchers and include sufficient references to allow in depth exploration of the topic. More seasoned scientists could also benefit from this book as they venture into new areas of research." ( Journal of American Society for Mass Spectrometry , 6 October 2012)
Pressezitat
"In summary, this handbook presents research from a variety of areas tied together by the common thread of mass spectrometry. The authors present their works in a manner that is accessible to beginning researchers and include sufficient references to allow in depth exploration of the topic. More seasoned scientists could also benefit from this book as they venture into new areas of research." ( Journal of American Society for Mass Spectrometry , 6 October 2012)Kommentar zu "Mass Spectrometry Handbook"
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