Advanced Materials and Techniques for Biosensors and Bioanalytical Applications (PDF)

The primary research area of Prof. Goswami is biocatalysis and biosensors. His research involves the development of nano-bio sensors for malaria, myocardial infarction (MI), alcohol, and bilirubin. One of his primary objectives is the development of novel biorecognition systems along with signal transduction platforms for the above targets. His group has developed many novel aptamers as recognition molecules for the detection of malaria and MI. Efficient signal transduction through nanomaterial interface for sensitive and selective detection of the targets is the primary activity in his research lab. In this aspect, his group explores the direct electron transfer from the biorecognition elements (enzyme and bacterial biocatalysts) to the electrode surface through various electrochemical transducing platforms to generate a seamless electrical signal for sensing applications. His achievement on direct electrical communication from the FAD-based very high molecular weight redox enzymes, mainly, alcohol oxidase is well known. Prof. Goswami has used the concept to develop not only a sensitive amperometric alcohol biosensor but also a prototype on enzymatic-biofuel cell cum bio-battery using the enzyme bioelectrode. Among the different electrochemical transducers, Prof. Goswami's lab is well known for enzyme and cyanobacteria based biofuel cells as signal-transducing platforms for generation and amplification of signals to detect alcohol and allied applications. A couple of proofs-of-concept his group has developed through the intensive basic research has already been translated to portable kits for detection of malaria, alcohol, methanol, and formaldehyde. Prof. Goswami has published more than 100 peer-reviewed scientific papers and filed ten patent applications, mainly in the field of biosensors and biocatalysis. He has supervised more than 30 Ph.D. students and received many awards and accolades, including many outstanding reviewers' awards from reputed journals and visiting professorship in premiere university in abroad. He is also an editorial board member of some international scientific journals.