Alternatives to Animal Testing (PDF)

From the Contents: Looking Back 33 Years to Russell and Burch/ The OECD and International Regulatory Acceptance of the Three Rs/ The European Centre for the Validation of Alternative Methods (ECVAM)/ A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests/ The Fund for the Replacement of Animals in Medical Experiments (FRAME)/ Animal Use and Alternatives/ The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines/ ZEBET/ Reviewed Literature Databank for Alternatives to Animal Experiments/ The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology/ Computer-Aided Drug Design and the Three Rs/ Computer-Aided Programs in Biomedical Education/ Alternatives to Experiments with Animals in Medical Education/ Replacement of Laboratory Animals in the Management of Blood-Sucking Arthropods/ Maintenance of Filarial Cycles in the Laboratory/ Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System/ Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures/ European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin 2TM Model ZK1100) Using 18 Chemicals and Formulated Products/ Cellular Assays for Testing Peritoneal Dialysis Bags/ The Position of the Authorities

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