Biological Psychiatry (ePub)

Acknowledgements. Quotations. Preface to the First Edition. Preface to the Second Edition. Introduction and Preface to the Third Edition. 1 Principles of Brain Function and Structure: 1 Genetics, Physiology and Chemistry. Introduction. Genetics. Brain chemistry and metabolism. The metabolism of glucose. Proteins and fatty acids. Cell membranes. Synapses. Receptors. Neurones. Neurotransmitters. Interrelationships among transmitters. Transmitter dispersal. CNS inflammation. 2 Principles of Brain Function and Structure: 2 Anatomy. Introduction. The neuroanatomy of emotion. Individual anatomical structures. Ascending and descending limbic-system connections. Macrosystems. The basal ganglia and the re-entrant circuits. The ventral striatum and 'limbic striatum'. The ascending cholinergic systems. Cortical regions of interest. The cerebellum. 3 Important Brain-Behaviour Relationships. Introduction. Important anatomical structures for understanding behaviour. Some specific behaviours. Limbic lobe disorders in a clinical context. Re-entrant circuits in a clinical context. The frontal lobes in a clinical context. Laterality. 4 Classifications and Clinical Investigations. Introduction. Signs, symptoms, syndromes and disease. Classification in psychiatry. Clinical investigation. 5 Personality Disorders. General introduction. Introduction to the concept of personality. Genetics. Somatic variables. Metabolic and biochemical findings. Neurophysiological and neurological data. Some outstanding issues. 6 Anxiety Disorders. Introduction. Genetics. Somatic variables. Metabolic and biochemical findings. Neurochemical investigations. Neurophysiological and neurological data. Imaging. Obsessive-compulsive disorder. Post-traumatic stress disorder. Some outstanding issues. 7 The Schizophrenias. Introduction. Genetics. Somatic variables. Metabolic and biochemical findings. Neurochemical investigations. Neurophysiological and neurological data. Some outstanding issues. 8 Affective

Professor Trimble was for many years Professor ofBehavioural Neurology and Consultant Physician to the Department ofPsychological Medicine at the National Hospital Queen Square,London. He now holds emeritus status at the above institutions. Hestudied general medicine, obtaining membership of the Royal Collegeof Physicians before going to the National Hospital Queen Squareand then the Maudsley Hospital to advance his training in neurologyand psychiatry. Following an internship in psychiatry at the JohnsHopkins Hospital, Baltimore, he returned to the National Hospitalto pursue a career in neuropsychiatry. He set up a research groupwith main interests in the interface disorders between neurologyand psychiatry, reflected in the developing recognition ofneuropsychiatry and behavioural neurology as independentdisciplines. The research group (Raymond-Way Unit) explored thebehavioural consequences of neurological disorders and theirtreatment, with a major interest in epilepsy and movementdisorders. His current writing and academic interests involveteaching and lecturing on neuroanatomical concepts relevant tounderstanding behaviour and its variations, in particular with aninterest in neuroaesthetics and neurotheology, namely the cerebralbasis of artistic and religious experiences.

Dr. George received his medical degree from the MedicalUniversity of South Carolina in Charleston in 1985, where hecontinued with dual residencies in neurology and psychiatry. He isboard certified in both areas. He worked for one year (1990-91) asa Visiting Research Fellow in the Raymond Way NeuropsychiatryResearch Group at the Institute of Neurology, London. He andProfessor Trimble used pharmacology and imaging to study theoverlaps between Obsessive-Compulsive Disorder and Gilles de laTourette Syndrome. During this year he also worked on newfunctional imaging techniques (SPECT and PET) at the Institute ofNuclear Medicine, University College of London and Middlesex Schoolof Medicine, London. He

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