Carbonic Anhydrases as Biocatalysts (ePub)

Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990 he became assistant and then associate professor of chemistry at the University of Bucharest. He was a visiting scholar at University of Florida, Gainesville, USA, at Grifitth University, Brisbane, Australia and visiting professor at University of La Plata, Argentina. In 1995 he moved at the University of Florence, Italy, where he is currently assistant professor of pharmaceutical chemistry. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 700 papers in these fields.

Giuseppina De Simone was born in Naples, Italy, and graduated in chemistry at the University of Naples Federico II (1993). She worked from August 1994 to January 1995 at the Drug Design Group-Sandoz Pharma AG in Basel, and from September 1995 to February 1996 at the University of Pavia. From November 1996 to January 1997 she was visiting scientist at the Max Plank Institute- Hamburg Germany. In 1998 she received her PhD at the University of Naples. Since 2003, she is Senior Researcher at the Institute of Biostructures and Bioimaging (IBB) of the Italian National Research Council. Her main research interests include X-ray crystallography of macromolecules, structure based drug design, carbonic anhydrases, serine proteases, esterases/lipases, peptide nucleic acids. She has published more than 90 papers in these fields.

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