Cytomegaloviruses (PDF)
Human Cytomegalovirus (CMV), a member of the herpesvirus family, is an under-rated health risk. Low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune system is intact, with primary infection thus...
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Human Cytomegalovirus (CMV), a member of the herpesvirus family, is an under-rated health risk. Low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune system is intact, with primary infection thus usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with life-long neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immunocompromised patients requiring either a solid organ graft or receiving a hematopoietic cell graft for the treatment of hematopoietic malignancies that are refractory to standard therapies. Under the condition of weakened immune surveillance in these patients, latent CMV hidden in transplanted donor cells or in the recipients' own tissues can awake to cause a destructive infection resulting in graft loss and multiple end-organ disease, of which viral pneumonia is the most feared. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models.
Bibliographische Angaben
- 2013, 488 Seiten
- Herausgegeben: Matthias J. Reddehase
- ISBN-10: 1908230843
- ISBN-13: 9781908230843
- Erscheinungsdatum: 15.04.2013
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