Genes, Environment and Alzheimer's Disease (ePub)

Dr. Orly Lazarov is an Associate Professor of Neuroscience in the Department of Anatomy and Cell Biology at the University of Illinois at Chicago. She received a Ph.D. in Neuroscience from the Weizmann Institute of Science in Israel. She was awarded the Feinberg Graduate School Fellowship of Distinction for Outstanding Achievement in Studies and Research and the Yashinsky Award of Excellence for Distinguished Ph.D. Students. During her postdoctoral training at the University of Chicago she studied molecular and cellular mechanisms underlying Alzheimer’s disease. In 2006 she accepted a tenure track Faculty position as an Assistant Professor at the University of Illinois at Chicago. Dr. Lazarov was the first to show that experience in a complex (enriched) environment ameliorates Alzheimer’s pathology in a rodent model of the disease. Dr. Lazarov’s research is aimed at understanding brain plasticity, particularly, neurogenesis, in relation to learning and memory and cognitive deterioration in Alzheimer’s disease.

Dr. Giuseppina Tesco is an Associate Professor (with tenure) at Tufts University. She received her MD and PhD from the University of Florence, Italy. She also completed her residency in Neurology at the University of Florence. In 1995, she was awarded a prestigious Fogarty Postdoctoral Visiting Fellow award to study the role of potassium channels in the learning and memory process and in Alzheimer’s disease at NINDS. In 1997, she joined the Department of Neurology at Massachusetts General Hospital and Harvard Medical School where she became Assistant Professor. In 2009 Dr. Tesco accepted a Faculty position at Tufts University. Her research focuses on Alzheimer’s Disease (AD). She identified a novel mechanism that regulates BACE1 levels and activity via the trafficking molecules GGA1 and GGA3 (golgi-localized gamma-ear-containing ARF binding protein 1-3). She was the first one to demonstrate that BACE1 is normally degraded in the lysosomes and that

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