Handbook of Toxicogenomics (PDF)

Introduction TECHNOLOGY PLATFORMS IN TOXICOGENOMICS Expression Profiling Using SAGE and cDNA Arrays Oligo Arrays, Global Transcriptom Analysis Toxicogenomics Applications of Open-Platform High Density DNA Microarrays Mass Spectrometry and Proteomics: Principles and Applications Covalent Protein Modification Analysis by Electrospray Tandem Mass Spectrometry Chromatin Immunoprecipitation-based Identification of Gene Regulatory Networks NMR Spectroscopy as a Versatile Analytical Platform for Toxicology Research BIOINFORMATIC TOOLS IN TOXICOGENOMICS Generation and Validation of a Reference System for Toxicogenomics DNA Microarray Experiments The Chemical Effects in Biological Systems (CEBS) Knowledge Base Investigating the Effective Range of Agents Using Integrative Modelling Databases and Tools for In-silico Analysis of Regulation of Gene Expression System Biology Applied to Toxicogenomic APPLICATION OF TOXICOGENOMIC: CASE STUDIES Networks of Liver-enriched Transcription Factors in Liver Biology and Disease Toxicogenomics Applied to Understanding Cholestasis and Steatosis in the Liver Toxicogenomics Applied to Cardiovascular Toxicity Toxicogenomics Applied to Endocrine Disruption Toxicogenomics Applied to Teratogenicity Studies Toxicogenomics Applied to Nephrotoxicity Toxicogenomic Analysis of Human Umbilical Cords to Establish a New Risk Assessment of Human Fetal Exposure to Multiple Chemicals Genetic Variability: Implications for Toxicogenomic Research Profiling of Peripheral Blood Gene Expression to Search for Biomarkers How Things Could Be Done Better Using Toxicogenomics: A Retrospective Analysis Toxicogenomics Applied to Haematotoxicology THE NATIONAL TOXICOGENOMIC PROGRAM/ INITIATIVES The National Toxicogenomic Program Toxicogenomics: The Japanese Initiative POINT OF VIEW FROM REGULATORY AUTHORITIES Toxicogenomics in Need for an ICH Guideline? Experiences from the Past

Jürgen Borlak received a degree in biochemistry and a PhD in biochemical toxicology at the University of Reading, UK, in 1988. He was a Cancer Research Campaign-founded postdoctoral research scientist and in 1990 joined the Marion Merrel Dow Research Institute in Strasbourg, France, as Senior Research Biochemist. In 1998, he was appointed Director of the Center of Drug Research and Molecular Pharmacology at the Fraunhofer Institute of Toxicology and Experimental Medicine; the centre focuses largely on the molecular effects of drugs and xenobiotics, using a wide range of methods and technologies in cell biology, genomics and molecular biology. In 2000 Jürgen Borlak was habilitated in pharmacology and toxicology and received the venia legendi at the Medical School of Hannover. In 2002 he was appointed as full professor to the chair of Pharmaco- and Toxicogenomics at the Medical School of Hannover. He was also appointed as Professor of Molecular Anatomy at the Medical Faculty of the University Leipzig in 2003.
Jürgen Borlak is a member of, among others, the Biochemical Society, the Royal Society of Chemistry, the Society of Experimental Biology and the International Society for the Study of Xenobiotics. He is a reviewer for various scientific journals and appointed by the World Health Organisation as an expert on chemical and drug safety.

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