A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics
From the Bench to the Clinic
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical...
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A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.
Bibliographische Angaben
- Herausgegeben:Chen, Xiao-Dong
- Verlag: Academic Press
- EAN: 9780128119204
Inhaltsverzeichnis zu „A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics “
Part 1 Principles and Concepts1. What Can We Learn From This Book?Travis J. Block, David D. Dean and Xiao-Dong Chen2. Features of Mesenchymal Stem CellsStan Gronthos3. Maintenance and Culture of MSCsMilos Marinkovic, David D. Dean and Xiao-Dong Chen4. Manufacturing Mesenchymal Stromal Cell BanksJamie Hoover and Patrick J. HanleyPart 2 Promises and Challenges of MSC-Based Therapies5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic StrategiesMaxime Ruiz, Marie Maumus, Christian Jorgensen and Daniele Noel6. Mesenchymal Stem Cell Therapy in Graft Versus Host DiseaseShivaprasad Manjappa, Rizwan Romee and Armin Rashidi7. Systemic Lupus ErythematosusDandan Wang and Lingyun Sun8. Mesenchymal Stem Cell-Based Therapies for Repair and Regeneration of Skin WoundsShanmugasundaram Natesan, Randolph Stone, Rodney K. Chan and Robert J. Christy9. Myocardial InfarctionNatalia Rozwadowska and Maciej Kurpisz10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes MellitusJoseph Kim, John Z. Q. Luo and Luguang Luo11. Mesenchymal Stem Cell-Based Therapy for Chronic Kidney DiseaseMaria V. Irazabal, LaTonya J. Hickson and Alfonso Eirin12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and ParkinsonismAshley Aaroe and Claire Henchcliffe13. Spinal Cord InjuryK. A. Ruppert, S. D. Olson and C. S. Cox14. Stem Cell-Based Restoration of Salivary Gland FunctionOlivia N. Tran, Hanzhou Wang, David D. Dean, Xiao-Dong Chen and Chih-Ko Yeh15. Tooth and Dental Pulp RegenerationBei Li, Chen Xi and Yan JinPart 3: Future Perspectives 16. MSCs as Biological DrugsThekkeparambil Chandrabose Srijaya, Sandhya Sriram, Noor Hayaty Abu Kasim and Shigeki Sugii17. Mesenchymal Stem Cell-Derived Products for Tissue Repair and RegenerationAnand Srinivasan, Michelle Lynn Fults, Peter Supronowicz, Roberto Esquivel and Rogelio Zamilpa18. Use of MSCs in Antiaging StrategiesTravis J. Block, David D. Dean and Xiao-Dong
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Chen19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and BrazilAchim Rosemann, Gabriela Bortz and Federico Vasen
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