Advances in Cancer Research
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Bibliographische Angaben
- Herausgegeben:Tew, Kenneth D.; Fisher, Paul B.
- Verlag: Academic Press
- EAN: 9780128047880
Autoren-Porträt
Professor & Chairman, Dept of Cell & Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USAThe Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.
Inhaltsverzeichnis zu „Advances in Cancer Research “
1. The Dual Role of Senescence in Pancreatic Ductal AdenocarcinomaAngelo Porciuncula, Cristina Hajdu and Gregory David
2. Small Molecule Targeting of BET Proteins in Cancer
Christopher A. French
3. H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer
Jessica N. Nichol, Daphné Dupéré-Richer, Teresa Ezponda, Jonathan D. Licht, Wilson H. Miller and Jr.
4. AEG1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity and CNS Diseases
Luni Emdad, Swadesh K. Das, Bin Hu, Timothy Kegelman, Dong-chul Kang, Seok-Geun Lee, Devanand Sarkar and Paul B. Fisher
5. Role of the RB Interacting Proteins in Stem Cell Biology
M. Mushtaq, H. Viñas Gaza and E.V. Kashuba
6. Evolving Strategies for Therapeutically Targeting Cancer Stem Cells (CSCs)
Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar and Paul B. Fisher
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