Klotho

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

1. Klotho-Related Protein KLrP: Structure and Functions Yasuhiro Hayashi and Makoto Ito 2. The FGF21 Receptor Signaling Complex: KLOTHO?, FGFR1c and Other Regulatory Interactions Dawn M. Kilkenny and Jonathan V. Rocheleau 3. Klotho-Dependent Cellular Transport Regulation Mentor Sopjani and Miribane Dërmaku-Sopjani 4. Klotho and the Growth Hormone/Insulin-like Growth Factor 1 Axis: Novel Insights Into Complex Interactions Tami Rubinek and Dalit Modan-Moses 5. Klotho Prevents Translocation of NF?B Paula Buendía, Rafael Ramírez, Pedro Aljama and Julia Carracedo 6. The FGF23/KLOTHO Regulatory Network and its Roles in Human Disorders Saori Kinoshita and Masanobu Kawai 7. MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity Ting Fu and Jongsook Kim Kemper 8. The Role of Alpha-Klotho as a Universal Tumor Suppressor Tami Rubinek and Ido Wolf 9. Klotho is a Neuroprotective and Cognition-Enhancing Protein Carmela R. Abraham, Patrick C. Mullen, Tracey Tucker Zhou, Cidi Chen and EllaZeldich 10. Function and Change with Aging of a-Klotho in the Kidney Keiko Akasaka-Manya, Hiroshi Manya and Tamao Endo 11. aKlotho and Chronic Kidney Disease Javier A. Neyra and Ming Chang Hu 12. Deficiency of Soluble a-Klotho as an Independent Cause of Uremic Cardiomyopathy Jian Xie, Yueh-Lin Wu and Chou-Long Huang