Oncogenomics

PART I: MOLECULAR MEDICINE: A NOVEL APPROACH TO CANCER INVESTIGATION 1. FROM THE DOUBLE HELIX TO ONCOGENOMICS AND PRECISION CANCER MEDICINE: AN EVOLVING STORY Franco Dammacco and Franco Silvestris 2. INTRATUMOR HETEROGENEITY: BIOLOGICAL AND CLINICAL IMPLICATIONS Rekha Gyanchandani, Nolan Priedigkeit, Ahmed Basudan and Adrian V. Lee 3. THE ROLE OF PROTEOMICS IN CANCER RESEARCH Carolina Panis, Stephany Corre^a, Renata Binato and Eliana Abdelhay 4. NEXT-GENERATION SEQUENCING IN CLINICAL PRACTICE Umberto Malapelle, Pasquale Pisapia, Francesco Passiglia, Amélie Dendooven, Patrick Pauwels, Roberto Salgado and Christian Rolfo 5. CANCER EPIGENETICS: ABERRANT DNA METHYLATION IN CANCER DIAGNOSIS AND TREATMENT Hideyuki Takeshima, Harumi Yamada and Toshikazu Ushijima 6. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Farhadul Islam, Vinod Gopalan and Alfred King-Yin Lam 7. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Ahmad R. Safa 8. TARGETING THE HEDGEHOG AND NOTCH SIGNALING PATHWAYS IN CANCER STEM CELLS Ankita Borah and D. Sakthi Kumar 9. CANCER STEM CELLS IN MULTIPLE MYELOMA AND THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES Franco Dammacco, Patrizia Leone, Franco Silvestris, Vito Racanelli and Angelo Vacca

PART II: ONCOGENOMICS: CIRCULATING BIOMARKERS IN CLINICAL ONCOLOGY 10. BONE METASTASES FROM SOLID TUMORS: IN SEARCH OF PREDICTIVE BIOMARKERS FOR CLINICAL TRANSLATION Franco Silvestris, Stella D'Oronzo, Domenica Lovero, Raffaele Palmirotta and Franco Dammacco 11. LIQUID BIOPSY AND GENOMIC ASSESSMENT FOR LUNG CANCER: THE ROLE IN CLINICAL PRACTICE? Véronique Hofman, Simon Heeke, Maryline Allègra, Marius Ilié and Paul Hofman 12. PROGNOSTIC AND PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS Francesco Schettini, Mario Giuliano and Massimo Cristofanilli 13. CIRCULATING MIRNAS AS TUMOR BIOMARKERS Vikas Ghai, Inyoul Lee and Kai Wang 14. CIRCULATING DNA IN CANCER DIAGNOSIS AND PROGNOSIS Eveline E. Vietsch and AntonWellstein 15.