Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurodegeneration in Neural Trauma, Neurodegenerative Diseases, and Neuropsychiatric Disorders.- Neurochemical Aspects of Ischemic Injury.- Potential Neuroprotective Strategies for Ischemic Injury.- Neurochemical Aspects of Spinal Cord Injury.- Potential Neuroprotective Strategies for Experimental Spinal Cord Injury.- Neurochemical Aspects of Traumatic Brain Injury.- Potential Neuroprotective Strategies for Traumatic Brain Injury.- Neurochemical Aspects of Neurodegenerative Diseases.- Potential Therapeutic Strategies for Neurodegenerative Diseases.- Perspective and Direction for Future Developments on Neurotraumatic and Neurodegenerative Diseases.

Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, glutamate-induced neurotoxicity and neurological disorders. He has discovered the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) in brains from patients with Alzheimer disease. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and increases levels of eicosanoids that may be related to the loss of synapses, induction of neuroinflammation and oxidative stress in brains of patients with Alzheimer disease. Dr. Farooqui has published cutting edge research on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by lipidomics. He has previously authored five monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); Hot Topics in Neural Membrane Lipidology (2009), and Beneficial Effects of Fish Oil on Human Brain (2009). All monographs are published by Springer. Dr. Farooqui has also edited two books: "Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS" Nova Science Publishers, Hauppauge, N.Y (2010) and Molecular Aspects of Neurodegeneration and Neuroprotection, Bentham Science Publishers Ltd (2010).

From the reviews:"Farooqui summarizes the current knowledge about neurochemical aspects of trauma such as stroke and head injury and disease such as Alzheimer's and prion disease. The book can serve as a reference for researchers and clinicians ... . chapter projects future directions and developments in the field." (SciTech Book News, December, 2010)"Readers will find the book to be an excellent source of information about neurochemical changes that occur in many brain diseases. ... I can recommend this book to those who work in the field of neurotrauma or to those who are looking for a source of information about the many different neurochemical abnormalities that occur in neurotrauma or in neurodegenerative diseases. ... the book fills a major niche in this important area of research." (David H. Small, Journal of Alzheimer's Disease, Vol. 24, 2011)

From the reviews:

"Farooqui summarizes the current knowledge about neurochemical aspects of trauma such as stroke and head injury and disease such as Alzheimer's and prion disease. The book can serve as a reference for researchers and clinicians ... . chapter projects future directions and developments in the field." (SciTech Book News, December, 2010)

"Readers will find the book to be an excellent source of information about neurochemical changes that occur in many brain diseases. ... I can recommend this book to those who work in the field of neurotrauma or to those who are looking for a source of information about the many different neurochemical abnormalities that occur in neurotrauma or in neurodegenerative diseases. ... the book fills a major niche in this important area of research." (David H. Small, Journal of Alzheimer's Disease, Vol. 24, 2011)