Novel Therapeutic Proteins

- Foreword (Juergen Drews)

- Preface (Klaus Dembowsky and Peter Stadler)

INTRODUCTION AND OVERVIEW

- Medical Applications of Recombinant Proteins in Humans Gayle Delmonte Wetzel

RECOMBINANT HORMONES

- Clinical Applications of Recombinant Human Erythropoietin (Dimitrios Spentzos and Arthur J. Sytkowski)

- Human Recombinant Growth Hormone (Carmen Ariznavarreta Ruiz and Jesús A.F. Tresguerres)

- Human Recombinant Follicle Stimulating Hormone (Follitropin-a) (José A. Peinado, Colin M. Howles, and Jesús A.F. Tresguerres)

RECOMBINANT CYTOKINES AND THEIR RECEPTORS

- Granulocyte Colony Stimulating Factor (G-CSF) (Karl Welte)

- Interferon b-1b in Multiple Sclerosis (Bernd Aufdembrinke, Reinhard Horowski, and Joachim-Friedrich Kapp)

- TNF-a -Receptors as Recombinant Proteins in Treatment of Rheumatoid Arthritis (Hanns-Martin Lorenz and Joachim R. Kalden)

RECOMBINANT ENZYMES, ENZYME ACTIVATORS AND INHIBITORS

- Improvement of Principles of Nature: t-PA (Rolf G. Werner and Gerhard Heusel)

- The Clinical Development of Recombinant Coagulation Factor VIII (KogenateÒ) for the Treatment of Hemophilia A (Peter J. Larson)

- Aprotinin, Recombinant Aprotinin and Recombinant Aprotinin Mutants (Klaus Dembowsky and Werner Schroeder)

RECOMBINANT VACCINES

- Recombinant Hepatitis B Vaccines -- Characterization of the Viral Disease and Vaccine Production in the Methylotrophic Yeast, Hansenula polymorpha (Stephan Schaefer, Michael Piontek, Sang-Jeom Ahn, Adam Papendieck, Zbigniew A. Janowicz and Gerd Gellissen)

MONOCLONAL ANTIBODIES

- Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (Mark Sopwith)

- Antibody Therapy for Sepsis: Some Lessons Learned (Steven M. Opal)

- An Engineered Human Antibody for Chronic Therapy: CDP571 (Mark Sopwith and Sue Stephens)

- The Evolution of ReoPro(r) Clinical Development (Catherine F. Farrell, Elliot S. Barnathan and Harlan F. Weisman)

- Index

Klaus Dembowski ist als Diplomingenieur an der Technischen Universität Hamburg-Harburg tätig und hat eine Reihe erfolgreicher Bücher aus dem Themenkreis der Computer- und insbesondere der PC-Technik verfaßt.