Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive
Anti-nociceptive Activity of Naringin-co (II) Metal Complexes
(Sprache: Englisch)
The activities of flavonoid are believed to increase when they are coordinated with transition metal ions. An attempt was made to understand the contribution of the metal coordination & type of interaction between a flavonoid & metal ion & evaluation of its...
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The activities of flavonoid are believed to increase when they are coordinated with transition metal ions. An attempt was made to understand the contribution of the metal coordination & type of interaction between a flavonoid & metal ion & evaluation of its biological activity. In this study a new metal complex of Co(II) with naringin was synthesized & characterized by FT-IR, UV-VIS spectrophotometer. Groups of six mice were treated with Cobalt Naringin Complex (10 mg/kg body weight), administered IP. Different tests were used for evaluating the anti-nociceptive effect or the influence on behavior of the tested substances on thermal nociception, chemical nociception & spontaneous behavior. In the current study it has been evaluated that the complex has a Co(II) ion coordinated via 4 and 5 position of the flavonoid. The metal binds with the flavonoid in the ratio 1:2, which was confirmed by Jobs method. Our preliminary data for response latencies for hot-plate and tail- flick tests suggest that systemically administered CNC produces a significant analgesic effect under thermal thermal nociceptive stimulation. The spontaneous behavior assay shows a significant decrease of activity.
Autoren-Porträt von Rudra Narayan Sahoo, Lipsa Samal, Sudhanshu Sekhar Rout
Sahoo, Rudra NarayanRudra Narayan Sahoo, M Pharm, Assistant professor at Centurion University of Technology and Management, Bhubaneswar, Odisha, India. Continuing PhD at Siksha'O' Anusandhan (Deemed to be University), Bhubaneswar, India. His research area of interest is Formulation and Development, and Drug Delivery Systems.
Bibliographische Angaben
- Autoren: Rudra Narayan Sahoo , Lipsa Samal , Sudhanshu Sekhar Rout
- 2021, 56 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6203201340
- ISBN-13: 9786203201345
Sprache:
Englisch
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