ADME Processes in Pharmaceutical Sciences

Part 1: The basics of ADME processes.- Chapter 1-Introduction. Biopharmaceutics and Pharmacokinetics.- Chapter 2-Drug release.- Chapter 3-Drug Absorption.- Chapter 4-Drug Distribution.- Chapter 5-Drug Metabolism.- Chapter 6-Drug Excretion.- Chapter 7-Drug Delivery Routes.- Chapter 8-Compartmental Pharmacokinetic Models.- Chapter 9-Regulatory Requirements and Applications of Physiologically Based Pharmacokinetic Models.- Chapter 10-Drug Drug and Food Drug Interactions of Pharmacokinetic Nature.- Part 2: Specialized topics.- Chapter 11-Nanocarriers:  Delivery Routes.- Chapter 12-Advanced Techniques for Quality Assessment of Nanocarriers.- Chapter 13-Nanomedicines Obtained by Nanoprinting.- Chapter 14-Absorption, Distribution, Metabolism and Excretion of Biopharmaceutical Drug Products.- Chapter 15-In silico and in vitro ADME predictions.- Chapter 16-Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens.- Chapter 17-The Relationship Between Pharmacogenomics and Pharmacokinetics and Its Impact on Drug Choice and Dosing Regimens in Pediatrics.- Chapter 18-Bioavailability and Bioequivalence studies.- Chapter 19-Drug transporters - Physiological role and Their Impact on Pharmacotherapy.- Chapter 20-Blood Flow Distribution and Membrane Transporters As Determinant Factors Of Tissue Drug Concentration.

Prof. Alan Talevi obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata. He obtained the award for the best PhD thesis from the Argentinean Chemical Society (2008) and the Award to Scientific Production from the National University of La Plata (2016). He holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2010, and he is Full Professor of the Biopharmacy course at the Faculty of Exact Sciences, University of La Plata. He has published over 100 articles in periodicals and more than 50 book chapters and entries, mostly in the fields of drug discovery and pharmacokinetics. He was elected Head of the Department of Biological Sciences of the Faculty of Exact Sciences, University of La Plata, between 2015 and 2017. In 2018 he became the Head of the Laboratory of Bioactive Compound Research and Development (LIDeB, University of La Plata). External reviewer for several agencies and universities, including Argentinean National Agency of Scientific and Technical Promotion, the United Nations University, the National Science Center (Poland), KU Leuven (Belgium), CONCYTEC (Perú), UK Research and Innovation (UK). Argentinean Ministry of National Education, University of La República (Uruguay), National Agency of Scientific and Technical Promotion (Uruguay). Reviewer of more than 80 periodicals, including Nature Communications, Scientific Reports, Journal of Medicinal Chemistry, Journal of Chemical Information and Modelling, Journal of Molecular Graphics and Modelling, PLoS One, Expert Opinion on Drug Delivery, Expert Opinion on Drug Discovery, Expert Opinion on Drug Metabolism and Toxicology, European Journal of Medicinal Chemistry, European Journal of Pharmacology, International Journal of Pharmaceutics. Member of the editorial board of Current Therapeutic Research (2023 and continues) and the Latin American Journal of Pharmacy (2014 and continues).