Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
(Sprache: Englisch)
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this...
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To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Inhaltsverzeichnis zu „Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta “
1. The Contribution of Microscopy to the Study of Amyloid Plaques and to Amyloid-ß Fibrillogenesis J. ROBIN HARRIS 2. Transgenic Mouse Models for APP Processing and Alzheimer's Disease: Early and Late Defects Tom Van Dooren, Ilse Dewachter, Peter Borghgraef and Fred Van Leuven
3. Oxidative stress in Alzheimer's Disease: Implications for Prevention and Therapy CHRISTIAN BEHL
4. ß-Secretase, APP and Aß in Alzheimer's Disease ROBERT VASSAR
5. The Non-Amyloidogenic Pathway: Structure and Function of a-Secretases Elzbieta Kojro and Falk Fahrenholz
6. Amyloid ß Degradation: A Challenging Task for Brain Peptidases Laura Morelli, Ayelén Bulloj, María Celeste Leal and Eduardo M. Castaño
7. The Protective Role of Vitamin E in Vascular Amyloid ß-Mediated Damage Francisco José Muñoz, Montserrat Solé and Mireia Coma
8. Amyloid Accumulation and Pathogensis of Alzheimer's Disease: Significance of Monomeric, Oligomeric and Fibrillar Aß Charles C. Glabe
9. Cholesterol and Amyloid ß Fibrillogenesis Katsuhiko Yanagisawa
10. Alzheimer's b-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding Hideyo Inouye and Daniel A. Kirschner
11. The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease CHRISTOPHER EXLEY
12. Amyloid-ß Metal Interaction and Metal Chelation Math P. Cuajungco, Christopher, J. Frederickson and Ashley I. Bush
13. The Interaction of Amyloid-ß with ApoE Donald B. Carter
14. Clusterin and Alzheimer's Disease Miguel Calero, Agueda Rostagno, Blas Frangione and Jorge Ghiso
15. Acetylcholinesterase Interaction with Alzheimer Amyloid ß Nibaldo C. Inestrosa, Juan Paulo Sagaland Marcela Colombres
16. Membrane Disordering Effects of ß-Amyloid Peptides Gunter P. Eckert, W.G. Wood and Werner E. Müller
17. The Role of Alzheimer Aß Peptides in Ion Transport Across Cell Membranes Vernon M. Ingram
18. Amyloid Inhibitors and ß-Sheet Breakers Claudio Soto and Lisbell Estrada
19.
... mehr
Cholesterol and Alzheimer's Disease: Statins, Cholesterol Depletion in APP Processing and Aß Generation Tobias Hartmann
20. Phosphorylated Amyloid-ß: The Toxic Intermediate in Alzheimer's Disease Neurodegeneration NATHANIEL G. N. MILTON
- Index
20. Phosphorylated Amyloid-ß: The Toxic Intermediate in Alzheimer's Disease Neurodegeneration NATHANIEL G. N. MILTON
- Index
... weniger
Bibliographische Angaben
- 2014, 2005, XVII, 409 Seiten, Maße: 15,2 x 22,9 cm, Kartoniert (TB), Englisch
- Herausgegeben: J. Robin Harris, Falk Fahrenholz
- Verlag: Springer, Berlin
- ISBN-10: 1461498414
- ISBN-13: 9781461498414
Sprache:
Englisch
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