Analysis of codon usage bias of Congo
(Sprache: Englisch)
Crimean-Congo hemorrhagic fever virus (CCHFV) is a negative-sense, single stranded RNA virus with a three-segmented genome that belongs to the genus Nairovirus within the family Bunyaviridae. CCHFV uses Hyalomma ticks as a vector to infect humans with a...
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Crimean-Congo hemorrhagic fever virus (CCHFV) is a negative-sense, single stranded RNA virus with a three-segmented genome that belongs to the genus Nairovirus within the family Bunyaviridae. CCHFV uses Hyalomma ticks as a vector to infect humans with a wide range of clinical signs, from asymptomatic to Zika-like syndrome. Despite significant progress in genomic analyses, the influences of viral relationships with different hosts on overall viral fitness, survival, and evading the host's immune systems remain unknown. To better understand the evolutionary characteristics of CCHFV, we performed a comprehensive analysis of the codon usage pattern in 179 CCHFV strains by calculating the relative synonymous codon usage (RSCU), effective number of codons (ENC), codon adaptation index (CAI), and other indicators. The results indicate that the codon usage bias of CCHFV is relatively low. Several lines of evidence support the hypothesis that a translation selection factor is shaping codon usage pattern in this virus.
Autoren-Porträt
Rahman, Siddiq UrDr. Siddiq Ur Rahman works at Khushal Khan Khattak University, Karak. His research interests are: host-pathogen interactions in a different emerging pathogen, using functional genomics and bioinformatics; big data / NGS analysis; functions of mRNA secondary structure and codon usage bias during translation elongation.
Bibliographische Angaben
- 2020, 60 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Herausgegeben von Rahman, Siddiq Ur
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139968003
- ISBN-13: 9786139968008
Sprache:
Englisch
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