Antibacterial Chemotherapeutic Agents

1 Introduction.- 1.1 History and overview of anti-infective chemotherapy.- 1.2 Infectious disease outbreaks and plagues.- 1.3 Common bacterial species.- 1.4 Sources of chemotherapeutic antibacterial agents and the impact of organic chemistry.- 1.5 Resistance.- 1.6 Current status and trends in antibacterial chemotherapy.- Further reading.- 2 Sulfa antibacterials and arylpyrimidine antifolates.- 2.1 History and overview.- 2.2 Mode of action: inhibition of bacterial folate metabolism.- 2.3 Structural features and structure-activity relationships of the sulfa antibacterials and arylpyrimidine antifolates.- 2.4 Synthetic approaches to sulfa antibacterials and arylpyrimidine antifolate antibacterial agents.- 2.5 Bacterial resistance to the sulfa antibacterials and arylpyrimidine antifolates.- 2.6 New agents.- 2.7 Summary.- Further reading.- 3 ß-Lactam antibiotics.- 3.1 History and overview.- 3.2 Mode of action: penicillin-binding proteins and inhibition of transpeptidation.- 3.3 Structural features and structure-activity relationships of the ß-lactam antibacterials.- 3.4 Synthesis of ß-lactam antibacterials.- 3.5 Bacterial resistance to the ß-lactam antibacterial agents.- 3.6 Recent advances.- 3.7 Summary.- Further reading.- 4 Tetracycline antibiotics.- 4.1 History and overview.- 4.2 Mode of action: bacterial protein synthesis inhibition.- 4.3 Structural features and structure-activity relationships of the tetracycline antibacterials.- 4.4 Synthetic approaches to tetracycline antibacterial agents.- 4.5 Uptake and bacterial resistance to tetracycline antibacterial agents.- 4.6 Recent advances.- 4.7 Summary.- Further reading.- 5 Aminoglycoside antibiotics.- 5.1 History and overview.- 5.2 Mode of action: bacterial protein synthesis inhibition.- 5.3 Structural features andstructure-activity relationships of the aminoglycoside antibacterials.- 5.4 Synthetic approaches to aminoglycoside antibacterial agents.- 5.5 Bacterial resistance to aminoglycoside antibacterials.- 5.6