Applied Biopharmaceutics & Pharmacokinetics
(Sprache: Englisch)
A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokineticsThe field's leading text for more than three decadesApplied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic...
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A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokineticsThe field's leading text for more than three decadesApplied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to:Understand the basic concepts in biopharmaceutics and pharmacokinetics.Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and elimination
Critically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalency
Design and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parameters
Detect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve them
Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.
Inhaltsverzeichnis zu „Applied Biopharmaceutics & Pharmacokinetics “
PrefaceGlossary
1. Intrtoduction to Biopharmaceutics and Pharmacokinetics
2. Mathematical Fundamentals in Pharmacokinetics
3. One-compartment Open Model: Intravenous Bolus Administration. 4. Multicompartment Models: Intravenous Bolus Administration
5. Intravenous Infusion
6. Drug Elimination and clearance
7. Pharmacokinetics of Oral Absorption
8. Multiple-Dosage Regimens
9. Monlinear Pharmacokinetics
10. Physiologic Drub Distribution and Protein Binding
11. Drug Elimination and Hepatic Clearance
12. Pharmacogenetics
13. Physioloic Factors Related to Drug Absorption
14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance
15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence
16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy
17. Modified-Release Drug Products
18. Targeted Drug Delivery Symptoms and Biotechnological Products
19. Relationship Between Pharmacokeinetics and Pharmacodynamics
20. Application of Pharmacokinetics to Clinical Situations
21. Dose Adjustment in Renal and Hepatic Disease. 22. Physiology Pharmacokinetic Models, Mean residence Time, and statistical Moment Theory
Appendix A Statistics
Appendix B Applications of Computer in Pharmacokinetcs
Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions
Appendix D Guiding Prinicples for Human and Animal Research
Appendix E Popular Drugs and Pharmacokinetic Parameters
Index
Autoren-Porträt von Leon Shargel, Susanna Wu-Pong, Andrew Yu
McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide
Bibliographische Angaben
- Autoren: Leon Shargel , Susanna Wu-Pong , Andrew Yu
- 2012, 6th ed., 811 Seiten, Maße: 19,7 x 24,9 cm, Gebunden, Englisch
- Verlag: McGraw-Hill Professional
- ISBN-10: 007160393X
- ISBN-13: 9780071603935
Sprache:
Englisch
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