Approaching Complex Diseases

Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti).- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras).- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi).- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey).- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde).- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki).- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain).- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent).- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovicová , Daniel Rosel , Jan Brábek).- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva).- Chapter 11. Targeting the tumor-associated macrophages for 'normalizing' cancer (Julia Kzhyshkowska).- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina).- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine).- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter,

Mariano Bizzarri PhD, M.D ., is Associate Professor of Clinical Pathology in the Department of Experimental Medicine at University Sapienza, Rome (Italy). He was appointed as member of the Italian Space Agency (ASI) Scientific Committee in 2005 and he was elected President of that Committee in 2011-2014. He is a co-founder of the Italian Society for Space Biomedicine and Biochemistry (2006). Head of the Interdepartmental Systems Biology Center and member of the Space Research Interdepartmental Center of the University La Sapienza (CRAS). He is the Editor in Chief of the international journal ORGANISMS. He has authored hundreds of scientific and philosophical essays, as well as of dozen of scientific books, among which Systems Biology (Springer protocols, 2017).