Biological Signal Transduction

I. Receptor Characteristics, Function and Regulation.- The nicotinic acetylcholine receptor: a member of the superfamily of ligand-gated ion channels.- Epidermal growth factor receptor autophosphorylation is not required for normal mitogenic or transforming signal generation.- The epidermal growth factor receptor: receptor dimerization and signal transduction.- Dimerization activates the epidermal growth factor receptor tyrosine kinase.- Insulin-related peptides and their receptor(s) in the mollusc, Lymnaea stagnalis.- Hepatic vasopressin receptor: a key receptor of phosphoinositide metabolism.- Gene targeting by homologous recombination as a tool to study the biophysical role of the interferon-? signalling pathway.- Expression of novel cloned rat pituitary receptors in mammalian cells.- Cellular localization of seven transmembrane domain receptor mRNA's by in-situ hybridization.- The T cell activation molecule CD27 is a member of the nerve growth factor receptor gene family.- Membrane receptor clustering as a cellular stimulus - the mast cell case.- II. G-Proteins and Protein Kinases.- G protein-coupled receptors: structural basis of selective signaling.- Hormone receptor-effector coupling in prolactin producing pituitary cell lines (GH cells)..- Effect of aging on the ?-adrenergic signal transduction system in rat kidney, lung, and mononuclear leukocytes.- The transducin cycle in the phototransduction cascade.- Expression of two isoforms of the guanine nucleotide binding protein, G0, in NG108-15 neuroglioma cells.- Mechanisms underlying hormonal modification of dopamine receptor sensitivity.- Phosphorylation of the growth factor activatable Na+/H+ antiporter: a mechanism of regulation.- Overexpression of protein kinase C ? in Swiss/3T3 cells reduces thenumber of both high and low affinity of the epidermal growth factor receptors.- Characterization of protein kinase C isoforms in a small cell lung carcinoma cell line: regulation of PKC? and its catalytic fragment.-

Specialists in biochemistry and cell biology of cellular communication give an overview of current knowledge in this field.